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Basic science
Original research
Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study
  1. René Aquarius1,2,
  2. Debby Smits3,
  3. Matthew J Gounis4,5,
  4. William P J Leenders2,
  5. Joost de Vries1
  1. 1Department of Neurosurgery, Radboud University Medical Center, Nijmegen, The Netherlands
  2. 2Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands
  3. 3Central Animal Laboratory, Radboud University Medical Center, Nijmegen, The Netherlands
  4. 4University of Massachusetts Medical School, Worcester, Massachusetts, USA
  5. 5Department of Radiology, Division of Neuroimaging and Intervention, New England Center for Stroke Research, Worcester, Massachusetts, USA
  1. Correspondence to Dr René Aquarius, Radboud University Medical Center, Department of Neurosurgery/Pathology (846), P O Box 9101, 6500 HB Nijmegen, The Netherlands; rene.aquarius{at}radboudumc.nl

Abstract

Background More challenging animal models are needed to elucidate the efficacy of flow diverter (FD) designs and the mechanisms behind observed complications. The purpose of this study is to demonstrate the feasibility of implanting a FD in a sidewall aneurysm rat model.

Methods An end-to-side anastomosis was created in the abdominal aorta of 36 rats using a decellularized donor pouch. A FD was subsequently implanted.

Results After up to 3 months of follow-up, we observed that rats displayed normal growth and behavior. Mortality within the groups was low (2 rats, 5.6%). All aneurysms thrombosed after FD implantation and showed progressive soft tissue replacement of the thrombus during follow-up. The abdominal aortas remained patent.

Conclusions This model can be used to test the effects of FDs in future studies.

  • Flow Diverter
  • Aneurysm
  • Technique
  • Artery

https://doi.org/10.1136/neurintsurg-2016-012878

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    Footnotes

    • Contributors RA, MJG, WPJL, JdV: conception, design. RA, DS: data acquisition, data analysis. RA: drafting the manuscript. DS, MJG, WPJL, JdV: revising the manuscript. RA, DS, MJG, WPJL, JdV: final approval of the submitted manuscript.

    • Funding This work was supported by Stryker Neurovascular.

    • Competing interests MJG: research grants (money paid to institution): NIH, CereVasc LLC, Gentuity LLC, Philips Healthcare, Cook Medical, Neurogami, Codman Neurovascular, Microvention/Terumo, Stryker Neurovascular, Advanced Catheter Therapies, Medtronic Neurovascular, Wyss Institute, InNeuroCo, Bracco, Neuravi; fee-per-hour consulting: Codman Neurovascular, Stryker Neurovascular; travel support to Clot Consensus Group Meeting: Neuravi; stock: InNeuroCo; honorarium: Mt Sinai Department of Neurosurgery. JdV: research grants (money paid to institution): Stryker Neurovascular; fee-per-hour consulting: Stryker Neurovascular.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data sharing statement Unpublished data available upon request.