rss
J NeuroIntervent Surg 1:56-65 doi:10.1136/jnis.2009.000083
  • New devices

Curative cerebrovascular reconstruction with the Pipeline embolization device: the emergence of definitive endovascular therapy for intracranial aneurysms

  1. P K Nelson6
  1. 1Division of Neurosurgery, State University of New York at Stony Brook, Stony Brook, New York, USA
  2. 2Division of Neurosurgery, ENERI Medical Institute, Equipo de Neurocirugía Endovascular y Radiología Intervencionista, Buenos Aires, Argentina
  3. 3Division of Neurosurgery and Neuroradiology, National Institute of Neurosurgery, Budapest, Hungary
  4. 4Division of Neurosurgery, Royal University Hospital, Saskatchewan, Canada
  5. 5Division of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona, USA
  6. 6Division of Neuroradiology and Neurosurgery, New York University, New York, New York, USA
  1. Correspondence to
    Dr D Fiorella, Department of Neurosurgery, Cerebrovascular Center, State University of New York at Stony Brook, Health Sciences Center T-12 080, Stony Brook, New York 11794–8121, USA; dfiorell{at}gmail.com
  • Received 1 April 2009
  • Accepted 3 April 2009
  • Published Online First 17 June 2009

Abstract

Endovascular, endosaccular, coil embolization has emerged as an established therapy for both ruptured and unruptured cerebral aneurysms. However, many aneurysms are not cured using conventional endovascular techniques. Coil embolization often results in incomplete aneurysm occlusion or recanalization in the ensuing months after treatment. The Pipeline embolization device (PED; Chestnut Medical) represents a new generation endoluminal implant which is designed to treat aneurysms by reconstructing the diseased parent artery. Immediately after implantation, the PED functions to divert flow from the aneurysm, creating an environment conducive to thrombosis. With time, the PED is incorporated into the vessel wall as neointimal–endothelial overgrowth occurs along the construct. Ultimately, this process results in the durable complete exclusion of the aneurysm from the cerebrovasculature and a definitive endoluminal reconstruction of the diseased parent artery.

Keywords:

Footnotes

  • Competing interests PN is a consultant and stockholder in Chestnut Medical.

 

Free Sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of JNIS.
View free sample issue >>

Access to JNIS


The Journal of NeuroInterventional Surgery forms part of the subscription to JNNP for both institutions and individuals. Individuals may subscribe separately to JNIS in print and/or Online: Subscribe here

SNIS members receive JNIS in print and can access the journal online via the members' area of the SNIS website

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.



SNIS logo



Navigate This Article