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030 Preliminary data for the dawn trial (DWI/PWI and CTP assessment in the triage of wake-up and late presenting strokes undergoing neurointervention): imaging based endovascular therapy for proximal anterior circulation occlusions beyond 8 h from last seen well in 193 stroke patients
  1. R Nogueira1,
  2. D Liebeskind2,
  3. R Gupta3,
  4. E Levy4,
  5. A Rai5,
  6. A Barreto6,
  7. O Zaidat7,
  8. N Janjua8,
  9. A Abou-Chebl9,
  10. D Yavagal10,
  11. M Rymer11,
  12. B Baxter12,
  13. A Furlan13,
  14. T Jovin14
  1. 1Interventional Neuroradiology and Endovascular Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA
  2. 2UCLA Medical Center, Los Angeles, California, USA
  3. 3Cleveland Clinic Foundation, Cleveland, Ohio, USA
  4. 4SUNY-Buffalo, Buffalo, New York, USA
  5. 5West Virginia University Health Sciences Center, Morgantown, West Virginia, USA
  6. 6University of Texas Medical School, Houston, Texas, USA
  7. 7Medical College of Wisconsin/Froedtert Hospital, Milwaukee, Wisconsin, USA
  8. 8State University of New York, Downstate Campus, Brooklyn, Massachusetts, USA
  9. 9University of Louisville School of Medicine, Louisville, Kentucky, USA
  10. 10University of Miami, Miami, Florida, USA
  11. 11Saint Luke's Hospital, Kansas City, Missouri, USA
  12. 12Erlanger Regional Stroke Center, Chattanooga, Tennessee, USA
  13. 13Case Western Reserve University, Cleveland, Ohio, USA
  14. 14University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Background: A large proportion of patients suffering acute strokes due to a proximal arterial occlusion present beyond the typical 8 h therapeutic window for endovascular intervention and thus are not considered candidates for reperfusion therapies. However, MRI perfusion and positron emission tomography studies have shown that a significant fraction of these patients have evidence of persistent penumbral tissue, suggesting the therapeutic window may be protracted in selected cases. We therefore hypothesized that imaging based endovascular therapy in wake up and late presenting stroke patients (defined as last seen well >8 h) is safe and potentially …

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