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Bioactivity and bioinactivity: two sides of the same coin
  1. Robert C Dawson
  1. Correspondence to Dr Robert C Dawson, Culicchia Neurological Clinic, 1111 Medical Center Blvd, Suite S-750, Marrero, LA 70072, USA; rcdawson3{at}cox.net

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In 1995, with ultimate confidence and supreme naiveté, I proposed that additives appended to platinum microcoils, might enhance the formation of a more stable histologic result, and thus produce a durable, or better still, a permanent cure. It is too often forgotten that the only worthwhile goal of any aneurysm treatment cannot be a ‘pretty angiogram’, or a high ‘packing density’, or any other subjective end-point, but rather, simply, a living and cured patient. This is not a subjective goal. The endless bean counting of ‘neck remnants’ and ‘dogears’, it seemed then, and I am convinced now, is a useless exercise, absent a direct linkage to clinical outcomes. For a number of theoretic and practical reasons, collagen was chosen by me and my fellow investigators as our …

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