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Complete angiographic obliteration of intracranial AVMs with endovascular embolization: incomplete embolic nidal opacification is associated with AVM recurrence
  1. Adam S Reig,
  2. Ravi Rajaram,
  3. Scott Simon,
  4. Robert A Mericle
  1. Department of Neurological Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
  1. Correspondence to Robert A Mericle, Department of Neurological Surgery, Vanderbilt University School of Medicine, T-4224 Medical Center North, Nashville, TN 37232, USA; robert.mericle{at}vanderbilt.edu

Abstract

Background Embolization of intracranial arteriovenous malformations (AVMs) is generally a preoperative adjunctive procedure in the USA. However, sometimes embolization can result in complete angiographic obliteration of the AVM. There is significant controversy regarding the best management strategy for this subset of patients. There is a scarcity of literature predicting which embolized, angiographically obliterated AVMs are likely to recur and which ones are cured. We present our series of patients with complete obliteration of their AVMs from embolization.

Methods A prospectively maintained database identified 122 patients who underwent embolization of an intracerebral pial AVM with liquid embolics. Eighteen patients (15%) achieved complete angiographic obliteration of the AVM with embolization. We followed several parameters to assess possible predictors of recurrence.

Results Fifteen of 18 patients (83%) had angiographic/anatomical follow-up to assess for AVM recurrence and 3 (17%) refused angiographic follow-up. Three patients underwent surgical resection with intraoperative angiography despite complete AVM obliteration with embolization alone. Thirteen of the 15 (87%) patients with follow-up remained obliterated at time of follow-up, and all of these patients had an embolic cast that had a similar morphology to the AVM nidus. Two of 15 patients (13%) had AVM recurrence, both of whom had incomplete embolic nidal opacification (proximal pedicle embolization).

Conclusions A minority of intracranial AVMs can be safely obliterated with stand-alone embolization. Proximal occlusion of feeding arteries appears to be associated with recurrence. Prospective studies with longer follow-up and larger patient numbers are necessary.

  • Arteriovenous malformation
  • endovascular
  • embolization
  • angiographic obliteration
  • artery
  • embolic
  • malformation
  • angiography
  • intervention
  • Received 28 September 2009
  • Revised 2 December 2009
  • Accepted 7 December 2009

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Footnotes

  • Competing interests The senior author (RAM) performs physician training and physician proctoring for Onyx HD 500, for which he receives compensation from eV3. No other author on this paper has any financial relationship of any sort with eV3 or any other company.

  • Ethics approval This study was conducted with the approval of the Vanderbilt University IRB.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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