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Original Research
1-Hexyl-2-cyanoacrylate compound (Neucrylate) bactericidal properties
  1. Peter Friedman1,
  2. Violeta Casillas1,
  3. Charles W Kerber2
  1. 1Valor Medical Inc, San Diego, California, USA
  2. 2Department of Radiology, UCSD Medical Center, San Diego, California, USA
  1. Correspondence to Dr P Friedman, Valor Medical, 6749 Top Gun St, Ste 109, San Diego, CA 92121, USA; pfriedman{at}valormedical.com

Abstract

Introduction The need for medical grade tissue adhesives both in surgery and to treat trauma has become well established. Such a device has been developed and preliminary toxicity testing completed on a compounded cyanoacrylate (Neucrylate), and its properties have been modified so it may be used as an intravascular embolic agent. Given the high incidence of iatrogenic infections in hospital, it would be desirable to have such an implantable device that inhibits dangerous bacteria.

Materials and method Seven separate cultures of common bacteria were grown and exposed to Neucrylate. The impact on the exposed microorganisms was analyzed visually as well as by means of fluorescence and optical microscopy.

Results The device produced high degrees of antibacterial effect when exposed to gram positive bacteria whereas it had modest impact on gram negative bacteria.

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Footnotes

  • Funding Valor Medical Inc.

  • Competing interests PF and VC are employed by VALOR Medical Inc. CWK is a stockholder in Valor Medical Inc.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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