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Original research
Analysis and quantification of endovascular coil distribution inside saccular aneurysms using histological images
  1. Hernán G Morales1,2,
  2. Ignacio Larrabide2,1,
  3. Arjan J Geers1,2,
  4. Daying Dai3,
  5. David F Kallmes3,
  6. Alejandro F Frangi1,2,4
  1. 1Center for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), Information and Communication Technologies Department, Universitat Pompeu Fabra, Barcelona, Spain.
  2. 2Networking Center on Biomedical Research (CIBER-BBN), Barcelona, Spain
  3. 3 Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
  4. 4 Department of Mechanical Engineering, University of Sheffield, Sheffield, Derbyshire, UK
  1. Correspondence to Hernán G Morales, Center for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), Information and Communications Technologies Department, Universitat Pompeu Fabra, c/Roc Boronat 138, E08018 Barcelona, Spain; hernan.morales{at}upf.edu

Abstract

Objective Endovascular coiling is often performed by first placing coils along the aneurysm wall to create a frame and then by filling up the aneurysm core. However, little attention has been paid to quantifying this filling strategy and to see how it changes for different packing densities. The purpose of this work is to analyze and quantify endovascular coil distribution inside aneurysms based on serial histological images of experimental aneurysms.

Method Seventeen histological images from 10 elastase-induced saccular aneurysms in rabbits treated with coils were studied. In-slice coil density, defined as the area taken up by coil winds, was calculated on each histological image. Images were analyzed by partitioning the aneurysm along its longitudinal and radial axes. Coil distribution was quantified by measuring and comparing the in-slice coil density of each partition.

Results Mean total in-slice coil density was 22.0±6.2% (range 10.1–30.2%). The density was non-significantly different (p=0.465) along the longitudinal axis. A significant difference (p<0.001) between peripheral and core densities was found. Additionally, the peripheral-core density ratio was observed to be inversely proportional to the total in-slice coil density (R2 =0.57, p <0.001). This ratio was near unity for high in-slice coil density (around 30%).

Conclusions These findings demonstrate and confirm that coils tend to be located near the aneurysm periphery when few are inserted. However, when more coils are added, the radial distribution becomes more homogeneous. Coils are homogeneously distributed along the longitudinal axis.

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