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E-011 the key role of the blood-brain barrier in the endovascular treatment of brain tumors and how to by-pass it: new methods
  1. S Peschillo1,
  2. F Diana2
  1. 1Department of Neurology and Psychiatry, Endovascular Neurosurgery/Interventional Neuroradiology, Policlinico Umberto I° – Sapienza University of Rome, Rome, Italy
  2. 2Department of Radiology, Radiology, Policlinico Umberto I° – Sapienza University of Rome, Rome, Italy

Abstract

Introduction/purpose Malignant gliomas (MG), remain challenging to treat due to their unresponsiveness to therapy. Promising new drugs are being evaluated, and new techniques have improved drug delivery through the blood brain barrier (BBB). Our aim is to assess the advantages and disadvantages of intra-arterial (IA) chemotherapy for treatment of MG and to investigate new ways to alter the BBB.

Materials and methods All the recent works were reviewed, from January 2002 till March 2015, regarding how to by-pass the BBB. We also have assessed the improvement of chemotherapy and clinical results after these treatments.

Results We have found new experimental techniques, such as focused ultrasound and new drugs, that could maximize the chemotherapy delivery through BBB.

Conclusion IA chemotherapy has been reported to be a promising new therapy; clinical studies are necessary to correlate this technique to the new ways of altering the BBB. Furthermore, these new methods could also be used in future scenarios before infusion of stem cells after stroke or brain trauma.

Disclosures S. Peschillo: 2; C; Penumbra. F. Diana: None.

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