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Original research
The Capillary Index Score before thrombectomy: an angiographic correlate of favorable outcome
  1. Paul-Emile Labeyrie1,
  2. Hocine Redjem1,
  3. Raphaël Blanc1,
  4. Marc-Antoine Labeyrie2,
  5. Bruno Bartolini1,
  6. Gabriele Ciccio1,
  7. Thomas Robert1,
  8. Boaz Gilboa1,
  9. Robert Fahed1,
  10. Marie Abrivard1,
  11. Michel Piotin1
  1. 1Department of Interventional Neuroradiology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
  2. 2Department of Neuroradiology, Hôpital Lariboisière, Paris, France
  1. Correspondence to M Piotin, Service de Neuroradiologie Interventionnelle, Fondation Rothschild, 25 rue Manin, Paris 75019, France; mpiotin{at}fo-rothschild.fr

Abstract

Background and purpose The angiography based Capillary Index Score (CIS) has recently emerged as a potential surrogate marker of cerebral perfusion before intra-arterial thrombolysis. We assessed the prevalence of a favorable CIS (f-CIS) and its relationship with clinical outcome in patients treated by mechanical thrombectomy (MT).

Methods Data from consecutive patients treated by MT from acute middle cerebral artery (MCA) occlusion were retrospectively analyzed. CIS was calculated from a pre-intervention cerebral angiogram. Association with favorable clinical outcome (modified Rankin Scale score ≤2) at 3 months was assessed in multivariate analysis.

Results 146 patients were included in the study. f-CIS was observed in 106/146 (72%) patients with an acceptable inter-rater agreement (κ=0.73, p<0.001). It was associated with a lower pretreatment National Institutes of Health Stroke Scale (NIHSS) score (p=0.014), an isolated M1/M2 occlusion without internal carotid occlusion (p=0.042), and an Alberta Stroke Program Early CT Score (ASPECTS) >4 (p=0.004). In binary regression, a favorable outcome was independently associated with f-CIS (OR (−95% CI, +95% CI)=3.8 (1.3 to 10.9), p=0.013), as well as NIHSS (p=0.007), ASPECTS (p=0.005), isolated M1/M2 occlusion (p=0.013), and age (p=0.032). The positive predictive value of f-CIS for a favorable outcome was 67%.

Conclusions f-CIS was strongly associated with a favorable outcome after MT of acute MCA occlusion. As an easy surrogate marker of cerebral perfusion, it may be a useful—albeit not sufficient—diagnostic test to select patients just before an MT or to manage them after recanalization.

  • Angiography
  • Stroke
  • Thrombectomy

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Footnotes

  • Contributors All authors contributed to this work according to the ICMJE guidelines for authorship: substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; and drafting the work or revising it critically for important intellectual content; and final approval of the version to be published; and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Competing interests None declared.

  • Ethics approval The study was approved by Fundation Rothschild Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement All additional unpublished data from the study are available on request by email to the corresponding author.

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