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Original research
Solitaire FR revascularization device 4×40: safety study and effectiveness in preclinical models
  1. John Michael Wainwright1,
  2. Reza Jahan2
    1. 1Department of R&D, Neurovascular, Medtronic, Irvine, California, USA
    2. 2Department of Interventional Neuroradiology, UCLA Medical Center, Los Angeles, California, USA
    1. Correspondence to Dr Reza Jahan, Interventional Neuroradiology, UCLA Medical Center, 757 Westwood Plaza, Suite 2129, Los Angeles, California 90095, USA; rjahan{at}mednet.ucla.edu

    Abstract

    Recent randomized clinical trials have shown the benefit of stent retrievers for endovascular intervention in patients with acute ischemic stroke. The Solitaire 2 FR 4×40 device was developed to address longer clots as well as procedural difficulties. This study was undertaken to evaluate the safety of the new device in a swine model at 0, 30, and 90 days as well as its in vitro effectiveness. There were no significant differences in the overall animal health, tissue injury, hemorrhagic or thrombogenic events related to device usage. Based on the comparison at multiple time points, the Solitaire 2 4×40 device was similar in safety and usability to the Solitaire 2 4×20 device. Due to the additional length of the device, the Solitaire 2 4×40 device may in fact provide a number of additional technical benefits in the neurothrombectomy treatment of ischemic stroke.

    • Stent
    • Thrombectomy
    • Stroke
    • Device

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