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O-020 WEB® Aneurysm Treatment: Preliminary Results of WEBCAST 2 Study
  1. L Pierot,
  2. A Molyneux,
  3. J Byrne
  1. Radiology, Hôpital Maison-Blanche, Reims, France

Abstract

Purpose WEB Flow disruption is an innovative endovascular treatment for wide-neck bifurcation aneurysms. This treatment was already evaluated in several retrospective and prospective series, including 2 Good Clinical Practice (GCP) studies (WEBCAST and French Observatory) showing high safety and good efficacy. In WEBCAST, all patients were treated with the first generation of the device (WEB-DL) and WEBCAST2 was initiated to evaluate the second generation of the device (WEB-SL and WEB-SLS).

Methods Patients with wide neck bifurcation aneurysm were included in WEBCAST2 if the aneurysm was not previously treated. An independent medical monitor independently analyzed adverse events. Follow-up imaging was obtained at 6 and 12 months up to 5 years after the procedure. An independent expert in Interventional Neuroradiology evaluated anatomical results using the 3 grades scale: complete occlusion, neck remnant, and aneurysm remnant.

Results From August 14 to May 15, 55 patients (38 females, 69.0%) with 55 aneurysms including 4 ruptured (7.2%) were included. Aneurysm locations were: middle cerebral artery in 25 patients (46.0%), anterior communicating artery in 16 patients (29.0%), basilar artery in 9 patients (16.0%), and internal carotid artery terminus in 5 patients (9.0%). Placement of the WEB device was feasible in 53/55 aneurysms (96.4%). Forty-seven aneurysms were treated with the WEB-SL and 6 with WEB-SLS. Adjunctive devices were used in 4 patients (7.3%). Procedure-related morbidity and mortality at one month were reported in 1/54 patients (1.8%) and 0/54 patients (0.0%), respectively (1 patient was missing one-month follow-up).

Anatomical results at 6 months were complete aneurysm occlusion in 28/49 aneurysms (57.1%), neck remnant in 11/49 aneurysms (22.4%), and aneurysm remnant in 10/49 aneurysms (20.4%).

Conclusion Preliminary results of WEBCAST2 show similar safety and efficacy of WEB-SL/SLS compared to WEB-DL (WEBCAST) with low morbidity and no mortality and a high rate of adequate occlusion (79.5%).

Disclosures L. Pierot: 2; C; Sequent. A. Molyneux: 2; C; Sequent. J. Byrne: 2; C; Sequent.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work noncommercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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