Article Text
Abstract
Background Recent guidelines for endovascular management of emergent large vessel occlusion (ELVO) award top tier evidence to the same selective criteria in recent trials. We aimed to understand how guideline adherence would have impacted treatment numbers and outcomes in a cohort of patients from a comprehensive stroke center.
Methods A retrospective observational study was conducted using consecutive emergent endovascular patients. Mechanical thrombectomy (MT) was performed with stent retrievers or large bore clot aspiration catheters. Procedural outcomes were compared between patients meeting, and those failing to meet, top tier evidence criteria.
Results 126 patients receiving MT from January 2012 to June 2015 were included (age 31–89 years, National Institutes of Health Stroke Scale (NIHSS) score 2–38); 62 (49%) patients would have been excluded if top tier criteria were upheld: pretreatment NIHSS score <6 (10%), Alberta Stroke Program Early CT score <6 (6.5%), premorbid modified Rankin Scale (mRS) score ≥2 (27%), M2 occlusion (10%), posterior circulation (32%), symptom to groin puncture >360 min (58%). 26 (42%) subjects had more than one top tier exclusion. Symptomatic intracerebral hemorrhage (sICH) and systemic hemorrhage rates were similar between the groups. 3 month mortality was 45% in those lacking top tier evidence compared with 26% (p=0.044), and 3 month mRS score 0–2 was 33% versus 46%, respectively (NS). After adjusting for potential confounders, top tier treatment was not associated with neurological improvement during hospitalization (β −8.2; 95% CI −24.6 to −8.2; p=0.321), 3 month mortality (OR=0.38; 95% CI 0.08 to 1.41), or 3 month favorable mRS (OR=0.97; 95% CI 0.28 to 3.35).
Conclusions Our study showed that with strict adherence to top tier evidence criteria, half of patients may not be considered for MT. Our data indicate no increased risk of sICH and a potentially higher mortality that is largely due to treatment of patients with basilar occlusions and those treated at an extended time window. Despite this, good functional recovery is possible, and consideration of MT in patients not meeting top tier evidence criteria may be warranted.
- Thrombectomy
- Stroke
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Footnotes
Contributors RB: contribution to conception of the work, data acquisition and analysis, and drafting and revising the manuscript. NG, KN, and AB: data acquisition. VTD, LE, DAH, and ASA: critical revision of the manuscript and approval of the final version. AVA and GT: substantial contribution to conception of the work, analysis and interpretation of the data, critically revising manuscript, and approval of the final version. AWA: critical revision of the manuscript for intellectual content and approval of the final version.
Competing interests ASA: consultant for Codman, Medtronic, Microvention, Penumbra, Sequent, Siemens, Silk Road, and Stryker; investor for Valor Medical; and research support from Codman, Penumbra, Sequent, and Siemens.
Ethics approval The study was approved by the institutional review board of the University of Tennessee Health Science Center.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement All authors are willing to share the database with authors interested in collaborative research.