Article Text

PDF
Original research
Predicting intraprocedural rupture and thrombus formation during coiling of ruptured anterior communicating artery aneurysms
  1. Lianghao Fan1,
  2. Boli Lin2,
  3. Ting Xu2,
  4. Nengzhi Xia2,
  5. Xiaotong Shao2,
  6. Xianxi Tan3,
  7. Ming Zhong3,
  8. Yunjun Yang2,
  9. Bing Zhao3,4
  1. 1Department of Interventional Radiology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China
  2. 2Department of Radiology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China
  3. 3Department of Neurosurgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China
  4. 4Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to Dr Bing Zhao, Department of Neurosurgery, or Dr Yunjun Yang, Department of Radiology, The First Affiliated Hospital, Wenzhou Medical University, Nanbai Xiang Town, 325000 Wenzhou, China; drzhaobing{at}yahoo.com, wzfskyyj2011{at}163.com

Abstract

Background Intraprocedural rupture and thrombus formation are serious complications during coiling of ruptured intracranial aneurysms, and they more often occur in patients with anterior communicating artery (ACoA) aneurysms.

Objective To identify independent predictors of intraprocedural rupture and thrombus formation during coiling of ruptured ACoA aneurysms.

Methods Between January 2008 and February 2015, 254 consecutive patients with 255 ACoA aneurysms were treated with coiling. We retrospectively reviewed intraoperative angiograms and medical records to identify intraprocedural rupture and thrombus formation, and re-measured aneurysm morphologies using CT angiography images. Multivariate logistic regression models were used to determine independent predictors of intraprocedural rupture and thrombus formation.

Results Of the 231 patients included, intraprocedural rupture occurred in 10 (4.3%) patients, and thrombus formation occurred in 15 (6.5%) patients. Patients with smaller aneurysms more often experienced intraprocedural rupture than those with larger aneurysms (3.5±1.3 mm vs 5.7±2.3 mm). Multivariate analysis showed that smaller ruptured aneurysms (p=0.003) were independently associated with intraprocedural rupture. The threshold of aneurysm size separating rupture and non-rupture groups was 3.5 mm. Multivariate analysis showed that a history of hypertension (p=0.033), aneurysm neck size (p=0.004), and parent vessel angle (p=0.023) were independent predictors of thrombus formation. The threshold of parent vessel angle separating thrombus and non-thrombus groups was 60.0°.

Conclusions Ruptured aneurysms <3.5 mm were associated with an increased risk of intraprocedural rupture, and parent vessel angle <60.0°, wider-neck aneurysms, and a history of hypertension were associated with increased risk of thrombus formation during coiling of ruptured ACoA aneurysms.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.