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Original research
Creation of sidewall aneurysm in rabbits: aneurysm patency and growth follow-up
  1. Yong Hong Ding1,
  2. Tai Tieu2,
  3. David F Kallmes1
  1. 1Department of Radiology, Neuroradiology Research Laboratory, Mayo Clinic, Rochester, Minnesota, USA
  2. 2MicroVention Inc, Tustin, California, USA
  1. Correspondence to Tai Tieu, MicroVention Inc, 1311 Valencia Avenue, Tustin, CA 92780, USA; tai.tieu{at}microvention.com

Abstract

Introduction To explore the patency and growth of surgical sidewall aneurysms in rabbits.

Materials and methods Forty sidewall aneurysms were created in the right common carotid artery (RCCA). Intravenous digital subtraction angiography (DSA) through the ear vein was performed immediately after creation. Three weeks later, intra-arterial DSA through the femoral artery was performed. Aneurysm sizes (neck, width, height and volume) were measured and calculated immediately after creation and 3 weeks later. Aneurysm patency after creation was evaluated. Differences in aneurysm sizes immediately after creation and 3 weeks later were compared using the Student's t test.

Results Aneurysms and the parent artery remained patent in 38 (95%) of the 40 rabbits 3 weeks after creation. Two other rabbits (5%) showed aneurysm occlusion. There was a significant difference in aneurysm neck size 3 weeks after creation (3.6±0.9 mm vs 2.4±0.4 mm, p<0.0001). The aneurysm became wider 3 weeks later (5.8±1.5 mm vs 4.3±1.2 mm, p<0.0001). Aneurysm length was also larger than immediately after creation (6.1±1.3 mm vs 4.3±1.4 mm, p<0.0001). The aneurysm volume was larger than that created immediately (127.5±89.4 mm3 vs 51.0±34.9 mm3, p<0.0001).

Conclusions The patency rate of sidewall aneurysms in rabbits is high. The aneurysm keeps growing for at least 3 weeks after creation.

  • Aneurysm

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