Introduction Previous studies have suggested a higher prevalence of intracranial aneurysms (IAs) in patients with aortic aneurysms (AAs).
Objective To carry out a preliminary study to evaluate the prevalence of IAs in these patients and the diagnostic feasibility of extended aorta CT angiography (CTA), including intracranial arteries as well as the aorta.
Materials and methods We retrospectively reviewed all patients with a clinical diagnosis of AA or aortic dissection (AD) who had undergone aorta CTA as well as MR angiography, CTA, and/or DSA of the brain between 2009 and 2014. Since 2012, the extended aorta CTA protocol has been applied in these patients. Characteristics of IAs were classified with baseline clinical data. For quantitative and qualitative assessment by two independent raters, brain images obtained by extended aorta CTA and brain CTA were compared. The radiation dose of the two aorta protocols was compared.
Results The prevalence of IA was 22.2% (35/158). All IAs were detected by extended aorta CTA, except one small aneurysm (<3 mm). The mean vascular attenuation value between brain images showed no difference (p=0.83), but the contrast-to-noise ratio was significantly lower in extended aorta CTA (p<0.001). In qualitative assessment, the interobserver agreement was substantial (k=0.79). For the radiation dose, the dose–length product of the extended aorta CTA increased with increment of the scan range (p=0.048).
Conclusions With a high prevalence of IAs in patients with ADs or AAs, extended aorta CTA could be used to evaluate aorta disease and IA in a single session. However, further prospective studies are needed to prove efficacy and safety of the extended aorta CTA protocol in patients with AAs or ADs.
- CT Angiography
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Correction notice This article has been corrected since it published Online First. The ‘material and methods – patients’ section has been amended.
Contributors All authors met the requirements for authorship. The corresponding author takes full responsibilities for the data, analyses, and interpretation, and the conduct of the research. The corresponding author had full access to all of the data and has the right to publish any and all data separate and apart from any sponsor. DL and SHS: substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; drafting the work or revising it critically for important intellectual content; final approval of the version to be published. YBK and S-WS: contributions to the conception or design of the work; acquisition of data for the work; final approval of the version to be published. WSJ, SJA and E-SC: contributions to the analysis of data for the work.
Funding This study was supported by a faculty research grant of Yonsei University College of Medicine (6-2015-0051).
Competing interests None declared.
Patient consent Obtained.
Ethics approval Ethics approval was obtained from the institutional review board committee of the Gangnam Severance Hospital, Yonsei University.
Provenance and peer review Not commissioned; externally peer reviewed.
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