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Case series
Predictors of false-positive stroke thrombectomy transfers
  1. Julia Yi1,
  2. Danielle Zielinski2,
  3. Bichun Ouyang3,
  4. James Conners3,
  5. Rima Dafer3,
  6. Michael Chen2
  1. 1University of Illinois at Chicago, Chicago, Illinois, USA
  2. 2Department of Neurological Surgery, Rush University Medical Center, Chicago, Illinois, USA
  3. 3Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA
  1. Correspondence to Dr Michael Chen, 1725 West Harrison Street, Suite 855, Chicago, IL 60612, USA; michael_chen{at}


Background Most patients with large vessel occlusion (LVO) stroke need to be transferred to receive thrombectomy. To save time, the decision to transfer often relies on clinical scales as a surrogate for LVO rather than imaging. However, clinical scales have been associated with high levels of diagnostic error. The aim of this study is to define the susceptibility to overdiagnosis of our current transfer decision process by measuring the rate of non-treatment transfers, the most common reasons for no treatment and potential predictors.

Methods Clinical and transfer data on consecutive patients transferred to a single endovascular capable centre for possible thrombectomy via stroke code activation were retrospectively reviewed. Whether patients underwent the procedure, why they did not undergo the procedure, and other clinical and logistical predictors were recorded. χ2 tests and multivariate logistic regression analysis were performed.

Results From 2015 to 2016, 105/192 transferred patients (54%) did not undergo thrombectomy and the most common reason was absence of a LVO found on CTA after transfer (71/104 (68%)). 14/16 (88%) with a National Institutes of Health Stroke Scale (NIHSS) score <10 did not undergo thrombectomy while 41/78 (52%) with a NIHSS>20 underwent thrombectomy (p<0.001). Helicopter use was associated with no treatment (p=0.004) while arrival within 5 hours was associated with treatment (p<0.001).

Conclusions Clinical scales appear to overdiagnose LVO and may be responsible for the majority of our stroke code transfers not undergoing thrombectomy. Primary stroke centres therefore have reason to develop the capability to rapidly acquire and interpret a CTA in patients with suspected LVO prior to transfer. Such efforts may reduce the costs associated with unnecessary thrombectomy transfers.

  • Economics
  • Stroke
  • Intervention

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  • Contributors All listed authors (JY, DZ, BO, JC, RD and MC) contributed to the design, data collection, data analysis and drafting of the manuscript.

  • Competing interests MC is a consultant for Genentech, Penumbra, Stryker and Medtronic.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement The authors agree to share any data on request.

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