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Original research
A systematic characterization of the factors influencing polymerization and dynamic behavior of n-butyl cyanoacrylate
  1. Bill H Wang1,
  2. Melfort Boulton1,2,
  3. Donald H Lee1,2,
  4. David M Pelz1,2,
  5. Stephen P Lownie1,2
  1. 1Department of Clinical Neurological Sciences, London Health Sciences Centre, London, Ontario, Canada
  2. 2Department of Medical Imaging, London Health Sciences Centre, London, Ontario, Canada
  1. Correspondence to Dr B H Wang, Department of Clinical Neurological Sciences, The University of Western Ontario, 339 Windermere Rd, London, Ontario, Canada N6A 5A5; billyhw{at}gmail.com

Abstract

Introduction Brain arteriovenous malformations are abnormal connections between arteries and veins without an intervening capillary bed. Endovascular glue embolization with N-butyl cyanoacrylate (NBCA) is an accepted form of treatment. The reported complication rates vary widely from 2% to 15%, and timing of polymerization appears to play a major role. Additionally, the interaction between NBCA and vessel surface as well as the presence of biological catalysts are poorly understood.

Methods Polymerization time was measured for mixtures of Lipiodol/NBCA of 50/50, 70/30, and 60/40. The influence of pH, temperature, and the presence of biological catalysts on polymerization time was investigated. Contact angles were measured on polyvinyl alcohol cryogel (PVA-C), silicone, and endothelial surfaces in a submerged aqueous environment to assess physical surface interactions. High speed video analysis of glue injection through a microcatheter was performed to characterize simulated coaxial flow.

Results NBCA polymerization rate increased with pH and temperature. A hydrophilic surface such as PVA-C was better than silicone at mimicking the physical properties of endothelium. Live endothelium provided a catalytic surface that at least doubled the rate of polymerization. Blood products further increased the polymerization rate in the following order (slowest to fastest): plasma, platelets, red blood cells (RBCs), and lysed RBCs. These factors could explain the discrepancy between in vitro and in vivo results reported in the current literature. High speed video analysis of NBCA injection showed dripping to jetting transition with significant wall effect which deviated from previous ideal assumptions.

Conclusions The determinants of NBCA polymerization rate are multifactorial and dependent mainly on the presence of biological catalysts coupled with flow related wall interaction.

  • Arteriovenous Malformation
  • Liquid Embolic Material
  • Intervention
  • Blood Flow

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Footnotes

  • Twitter Follow Bill Wang @BillyHWang and Steve Lownie @sabatboy

  • Contributors BHW: conceptual design, data acquisition, data analysis and interpretation, and manuscript composition. MRB: conceptual design of subcomponents of the project and manuscript revision. DHL and DMP: helped with interpretation of portions of the results given extensive clinical experience with NBCA, and manuscript revision. SPL: conceptual design, interpretation of the results, manuscript revision, and critical appraisal.

  • Funding This work was supported by the Canadian Institutes of Health Research, Canada Graduate Scholarships-Master's Program.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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