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Original research
Hemodynamic characteristics of stable and unstable vertebrobasilar dolichoectatic and fusiform aneurysms
  1. Waleed Brinjikji1,2,
  2. Bongjae Chung3,
  3. Ding Yong-Hong1,
  4. John T Wald1,
  5. Fernando Mut3,
  6. Ramanathan Kadirvel1,
  7. David F Kallmes1,2,
  8. Aymeric Rouchaud4,
  9. Giuseppe Lanzino1,2,
  10. Juan R Cebral3
  1. 1Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
  2. 2Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA
  3. 3Department of Bioengineering, Volgenau School of Engineering, George Mason University, Fairfax, Virginia, USA
  4. 4Department of Interventional Neuroradiology, Bicetre Hospital, Paris, France
  1. Correspondence to Dr Waleed Brinjikji, Department of Radiology, Mayo Clinic, Rochester, MN559005, USA; brinjikji.waleed{at}gmail.com

Abstract

Background and purpose Vertebrobasilar dolichoectatic and fusiform aneurysms (VBDAs) are known to have a poor natural history, with high rates of growth, rupture, and stroke. The purpose of this study was to identify hemodynamic characteristics that differ between VBDAs associated with growth, rupture, and stroke.

Materials and methods VBDAs with CT angiography or MR angiography followed longitudinally without treatment were studied. Unstable aneurysms were defined as those that grew or ruptured during follow-up. Aneurysms associated with stroke were defined as those associated with posterior circulation infarct at follow-up. Baseline data, including demographics, comorbidities, and aneurysm morphology and size were collected. Image based computational fluid dynamics models were created and run under pulsatile flow conditions. Relevant hemodynamic and geometric variables were calculated and compared between groups (stable vs unstable and no stroke vs stroke) using the Wilcoxon test.

Results A total of 37 VBDAs were included (24 stable, 13 unstable; 30 no stroke, 7 stroke). Unstable aneurysms had lower shear rates (P=0.05), blood flow velocity (P=0.03), and lower vorticity (P=0.049) than stable aneurysms. In addition, unstable aneurysms had higher mean oscillatory shear indices (P=0.001). There were no differences in the hemodynamic characteristics of aneurysms in the stroke group compared with the non-stroke group.

Conclusion This small study suggests there may be hemodynamic differences between unstable and stable VBDAs. Unstable VBDAs appear to be under lower flow conditions with lower velocity, vorticity, and shear rates, and have more oscillatory flow. There was no difference in the hemodynamic characteristics of aneurysms in the stroke and no stroke group.

  • aneurysm
  • hemodynamics
  • computational fluid dynamics

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Footnotes

  • Contributors All authors made (1) substantial contributions to conception or design of the work or the acquisition, analysis, or interpretation of data for the work; (2) drafting of the work or revising it critically for important intellectual content; (3) final approval of the version to be published; and (4) are in agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Funding This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

  • Competing interests WB: CEO of Marblehead Medical LLC and patents pending in balloon catheter technologies; consultant for Johnson and Johnson. DFK: President of Marblehead Medical LLC and patents pending in balloon catheter technologies.

  • Ethics approval The study was approved by the Mayo Clinic institutional review board.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Data could be made available by contacting the corresponding author via email.

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