TY - JOUR T1 - Neuroprotective strategies following intraparenchymal hemorrhage JF - Journal of NeuroInterventional Surgery JO - J NeuroIntervent Surg DO - 10.1136/neurintsurg-2017-013197 SP - neurintsurg-2017-013197 AU - Robin Moshe Babadjouni AU - Ryan E Radwanski AU - Brian P Walcott AU - Arati Patel AU - Ramon Durazo AU - Drew M Hodis AU - Benjamin A Emanuel AU - William J Mack Y1 - 2017/07/14 UR - http://jnis.bmj.com/content/early/2017/07/14/neurintsurg-2017-013197.abstract N2 - Intracerebral hemorrhage and, more specifically, intraparenchymal hemorrhage, are devastating disease processes with poor clinical outcomes. Primary injury to the brain results from initial hematoma expansion while secondary hemorrhagic injury occurs from blood-derived products such as hemoglobin, heme, iron, and coagulation factors that overwhelm the brains natural defenses. Novel neuroprotective treatments have emerged that target primary and secondary mechanisms of injury. Nonetheless, translational application of neuroprotectants from preclinical to clinical studies has yet to show beneficial clinical outcomes. This review summarizes therapeutic agents and neuroprotectants in ongoing clinical trials aimed at targeting primary and secondary mechanisms of injury after intraparenchymal hemorrhage. ER -