PT  - JOURNAL ARTICLE
AU  - Robin Moshe Babadjouni
AU  - Ryan E Radwanski
AU  - Brian P Walcott
AU  - Arati Patel
AU  - Ramon Durazo
AU  - Drew M Hodis
AU  - Benjamin A Emanuel
AU  - William J Mack
TI  - Neuroprotective strategies following intraparenchymal hemorrhage
AID  - 10.1136/neurintsurg-2017-013197
DP  - 2017 Jul 14
TA  - Journal of NeuroInterventional Surgery
PG  - neurintsurg-2017-013197
4099  - http://jnis.bmj.com/content/early/2017/07/14/neurintsurg-2017-013197.short
4100  - http://jnis.bmj.com/content/early/2017/07/14/neurintsurg-2017-013197.full
AB  - Intracerebral hemorrhage and, more specifically, intraparenchymal hemorrhage, are devastating disease processes with poor clinical outcomes. Primary injury to the brain results from initial hematoma expansion while secondary hemorrhagic injury occurs from blood-derived products such as hemoglobin, heme, iron, and coagulation factors that overwhelm the brains natural defenses. Novel neuroprotective treatments have emerged that target primary and secondary mechanisms of injury. Nonetheless, translational application of neuroprotectants from preclinical to clinical studies has yet to show beneficial clinical outcomes. This review summarizes therapeutic agents and neuroprotectants in ongoing clinical trials aimed at targeting primary and secondary mechanisms of injury after intraparenchymal hemorrhage.