RT Journal Article SR Electronic T1 X-ray angiography perfusion imaging with an intra-arterial injection: comparative study with 15O-gas/water positron emission tomography JF Journal of NeuroInterventional Surgery JO J NeuroIntervent Surg FD BMJ Publishing Group Ltd. SP neurintsurg-2017-013487 DO 10.1136/neurintsurg-2017-013487 A1 Katsunori Asai A1 Hajime Nakamura A1 Tadashi Watabe A1 Takeo Nishida A1 Manabu Sakaguchi A1 Jun Hatazawa A1 Toshiki Yoshimine A1 Haruhiko Kishima YR 2017 UL http://jnis.bmj.com/content/early/2017/12/04/neurintsurg-2017-013487.abstract AB Background X-ray angiography perfusion (XAP) is a perfusion imaging technique based on conventional DSA.Objective In this study, we aimed to validate parameters derived from XAP by comparing them with 15O-gas/water positron emission tomography (PET), using data from patients with chronic ischemic cerebrovascular disease.Methods 18 consecutive patients were included. XAP was performed with intra-arterial infusion of contrast media, and a time–density curve was constructed for each cerebral hemisphere. From the curves, the relative values of mean transit time (rMTT) and wash-in rate (rWiR) were obtained by dividing the values of the right hemisphere by those of the left hemisphere. These were then compared with the relative values of cerebral blood flow (rCBF) and rMTT calculated from the PET data.Results XAP rWiR correlated strongly with PET rCBF (r=0.86, P<0.0001). rMTT measurements from the two modalities were also strongly correlated (r=0.85, P<0.0001). Bland–Altman analysis revealed a bias of 0.14±0.18 (95% limits of agreement −0.22 to 0.51) for PET rCBF versus XAP rWiR, and 0.016±0.093 (95% limits of agreement −0.17 to 0.20) for rMTT between the two modalities.Conclusions The relative values obtained from XAP were validated across a population of patients with chronic ischemic cerebrovascular disease.