RT Journal Article
SR Electronic
T1 Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study
JF Journal of NeuroInterventional Surgery
JO J NeuroIntervent Surg
FD BMJ Publishing Group Ltd.
SP 88
OP 92
DO 10.1136/neurintsurg-2016-012878
VO 10
IS 1
A1 René Aquarius
A1 Debby Smits
A1 Matthew J Gounis
A1 William P J Leenders
A1 Joost de Vries
YR 2018
UL http://jnis.bmj.com/content/10/1/88.abstract
AB Background More challenging animal models are needed to elucidate the efficacy of flow diverter (FD) designs and the mechanisms behind observed complications. The purpose of this study is to demonstrate the feasibility of implanting a FD in a sidewall aneurysm rat model.Methods An end-to-side anastomosis was created in the abdominal aorta of 36 rats using a decellularized donor pouch. A FD was subsequently implanted.Results After up to 3 months of follow-up, we observed that rats displayed normal growth and behavior. Mortality within the groups was low (2 rats, 5.6%). All aneurysms thrombosed after FD implantation and showed progressive soft tissue replacement of the thrombus during follow-up. The abdominal aortas remained patent.Conclusions This model can be used to test the effects of FDs in future studies.