PT - JOURNAL ARTICLE AU - Vanessa Chalumeau AU - Raphaël Blanc AU - Hocine Redjem AU - Gabriele Ciccio AU - Stanislas Smajda AU - Jean-Philippe Desilles AU - Daniele Botta AU - Simon Escalard AU - William Boisseau AU - Benjamin Maïer AU - Julien Labreuche AU - Mickaël Obadia AU - Michel Piotin AU - Mikael Mazighi TI - Anterior cerebral artery embolism during thrombectomy increases disability and mortality AID - 10.1136/neurintsurg-2018-013793 DP - 2018 May 07 TA - Journal of NeuroInterventional Surgery PG - neurintsurg-2018-013793 4099 - http://jnis.bmj.com/content/early/2018/04/30/neurintsurg-2018-013793.short 4100 - http://jnis.bmj.com/content/early/2018/04/30/neurintsurg-2018-013793.full AB - Objective During thrombectomy, thromboembolic migration in previously unaffected territory may occur and is not systematically notified. We report our data on the incidence, predictors, and clinical outcome of anterior cerebral artery emboli (ACAE).Methods From a prospectively collected thrombectomy database of consecutive patients with anterior circulation stroke between January 2012 and December 2016, 690 angiographic images were analyzed to assess ACAE. The primary outcome was a favorable outcome, defined as a 3 month modified Rankin Scale score of 0–2 or equal to the pre-stroke score.Results ACAE occurred in 65 patients (9.4%; 95% CI 7.2% to 11.6%). Internal carotid artery occlusion (tandem or terminal), Alberta Stroke Program Early CT Score <7, increasing number of passes, and use of stent retriever alone (compared with distal aspiration alone or combined with stent retriever) were found to be independent predictors of ACAE. Compared with patients without ACAE, patients with ACAE had lower rates, with an adjusted OR (95% CI) of 0.48 (0.25 to 0.92; P=0.027) for favorable outcome and 0.49 (0.25 to 0.96; P=0.038) for early neurologic improvement. ACAE was significantly associated with a higher mortality (adjusted OR 1.93; 95% CI 1.03 to 3.61; P=0.039) and intracranial hemorrhagic complications (adjusted OR 2.45; 95% CI 1.33 to 4.47; P=0.004). Despite a successful reperfusion modified Thrombolysis in Cerebral Infarction score of 2b–3 at the end of the procedure, a favorable outcome was reached in 30% of patients with ACAE compared with 52.4% in the other patients (OR 0.39; 95% CI 0.19 to 0.78; P=0.008).Conclusions Procedural ACAE was not an uncommon condition, and was associated with increased mortality and disability rates, regardless of the success of reperfusion.