Relative expression of genes in flow diverter treated aneurysms compared with coiled aneurysms
| Gene name | Median (range) | Expression changes |
|---|---|---|
| Adhesion molecules | ||
| VCAM | 0.94 (0.11–661.7) | No change |
| Selectin E | 0.91 (0.19–1.54) | No change |
| Structural molecules | ||
| Collagen VIII | 0.82 (0.07–180.39) | No change |
| Collagen I | 0.18 (0.06–1.38) | ↓ |
| Fibronectin | 0.32 (0.08–0.36) | ↓ |
| Vascular remodeling | ||
| MMP-2 | 0.43 (0.09–2.42) | ↓ |
| MMP-9 | 0.36 (0.02–94.03) | ↓ |
| Cathepsin L | 0.25 (0.07–1.1) | ↓ |
| TIMP-1 | 2.4 (0.11–1.13) | ↑ |
| TIMP-2 | 0.18 (0.02–2.51) | ↓ |
| Growth factors/cytokines/inflammatory molecules | ||
| Osteopontin | 2.4 (0.11–133.9) | ↑ |
| Monocyte chemoattractant protein | 1.29 (0.37–5.35) | ↑ |
| TNFα | 1.37 (0.63–27.19) | ↑ |
| VEGF | 0.37 (0.28–1.13) | ↓ |
| Oxidative stress | ||
| HIF | 0.42 (0.06–251.6) | ↓ |
| HO-1 | 0.69 (0.15–1.84) | ↓ |
| Cellular markers | ||
| vWF | 0.35 (0.12–0.14) | ↓ |
| eNOS | 0.08 (0.02–0.14) | ↓ |
| SMA | 0.69 (0.34–0.72) | ↓ |
eNOS, endothelial nitric oxide synthase; HIF, hypoxia inducible factor; HO-1, heme oxygenase 1; MMP, matrix metalloproteinase; SMA, smooth muscle actin; TIMP, tissue inhibitor of MMP; TNFα, tumor necrosis factor α; VCAM, vascular cell adhesion molecule; VEGF, vascular endothelial growth factor; vWF, von Willebrand factor.