Intervention group characteristics
| Study name | Allocated to intervention group (n) | Received endovascular therapy (n (%)) | Received IA tPA (n (%)) | Mechanical thrombectomy (n (%)) | Time from onset to groin puncture (min) | mTICI of ≥2b (n)* | Treatment with IV tPA (n (%)) |
|---|---|---|---|---|---|---|---|
| ESCAPE | 165 | 151 (92) | NA | 151 (92) | 75† | 113 | 120 (73) |
| EXTEND-1A | 35 | 27 (77) | 0 | 27 (77) | 210 | 25 | 35 (100) |
| IMS-III‡ | 190 | 190 (100) | NA | NA | NA | 86§ | 190 (100) |
| MR CLEAN | 233 | 196 (84) | 24 (10) | 195 (84) | 260 | 115 | 203 (87) |
| SWIFT-PRIME | 98 | 87 (89) | NA | 87 (89) | 224 | 73 | 98 (100) |
| REVASCAT | 103 | 98 (95) | 1 (0) | 98 (95) | 269 | 67 | 70 (68) |
* mTICI score between 0 and 3; 0 is no perfusion and 3 is complete reperfusion. A score of ≥2b is considered successful reperfusion.
†Time from randomization to groin puncture.
‡Subgroup with CT angiography verified vessel occlusion.
§Successful recanalization was defined as grade 3–5 flow in previously occluded (grade 1–2) segments of symptomatic intracranial arteries on 24 h CT angiography and/or MR angiography.
Studies: ESCAPE, Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion with Emphasis on Minimizing CT to Recanalization Times; EXTEND, Extending the Time for Thrombolysis in Emergency Neurological Deficits; IMS-III, Interventional Management of Stroke-III; MR CLEAN, Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in The Netherlands; REVASCAT, Randomized Trial of Revascularization with Solitaire FR Device versus Best Medical Therapy in the Treatment of Acute Stroke Due to Anterior Circulation Large Vessel Occlusion Presenting within Eight Hours of Symptom Onset; SWIFT-PRIME, Solitaire with the Intention for Thrombectomy as Primary Endovascular Treatment.IA tPA, intra-arterial tissue plasminogen activator; mTICI, modified Thrombolysis in Cerebral Infarction; NA, assessed.