First row: the cumulative 3-year rate of acute ischemic strokes (AIS) and all M2 occlusions (3%, 95% CI 2 to 4) in the hospital’s four-county primary service area (PSA) with a population of 210 000. Second row: the annual incidence of AIS and M2 occlusions per 100 000 people in the PSA. Third row: the results extended to the US population for 2016 to generate an annual national incidence of M2 occlusions per 100 000 people