Procedure and outcome | All patients, (n=58) | Isolated M2 or M3 (n=31) | LVO+M2 or M3 (n=27) | Difference (95% CI)^{*} | p Value |

Time from symptom onset to groin puncture (median, IQR), min | 105 (95–120) | 105 (95–125) | 110 (95–120) | 0 (−10 to 10) | 0.9563 |

Time from symptom onset to recanalization (median, IQR), min | 130 (115–145) | 127.5 (115–145) | 130 (115–150) | 0 (−15 to 10) | 0.6646 |

Procedure duration (median, IQR), min | 54.3 (37–65) | 45.3 (30–55) | 63.5 (45–75) | −22 (−40 to 5) | 0.014 |

Post-treatment mTICI score 2b–3 (n/N (%)), per core laboratory | 58/58 (100%) | 31/31 (100%) | 27/27 (100%) | 0%, N/A | 1.0000 |

Post-treatment mTICI score 2b–3 (n/N (%)), per site PI | 53/58 (91.4%) | 28/31 (90.3%) | 25/27 (92.6%) | −2.3% (−27.4% to 23.4%) | 1.0000 |

Post-treatment mTICI score 3 (n/N (%)), per core laboratory | 48/58 (82.8%) | 24/31 (77.4%) | 24/27 (88.9%) | −11.5% (−36.4% to 14.1%) | 0.3110 |

Post-treatment mTICI score 3 (n/N (%)), per site PI | 41/58 (70.7%) | 22/31 (71.0%) | 19/27 (70.4%) | 1.0% (−25.0% to 26.1%) | 1.0000 |

Post-treatment NIHSS score (median, IQR) | 4 (3–6) | 4 (3–5) | 5 (3–7) | −1 (−2 to 0) | 0.1909 |

Good functional outcome at discharge, mRS 0–2 (n/N (%)) | 54/58 (93.1%) | 29/31 (93.5%) | 25/27 (92.6%) | 1.0% (−24.3% to 26.5%) | 1.0000 |

Good functional outcome at 90 days, mRS 0–2 (n/N (%)) | 55/58 (94.8%) | 30/31 (96.8%) | 25/27 (92.6%) | 4.2% (−21.3% to 29.6%) | 0.5931 |

Symptomatic ICH (n/N (%)) | 2/58 (3.4%) | 0/31 (0%) | 2/27 (7.4%) | −7.4% (−32.6% to 18.3%) | 0.2123 |

Asymptomatic ICH (n/N (%)) | 10/58 (17.2%) | 2/31 (6.5%) | 8/27 (29.6%) | −23.2% (−46.6% to 3.0%) | 0.0340 |

Vessel dissection (n/N (%)) | 0/58 (0%) | 0/31 (0%) | 0/27 (0%) | 0%, N/A | 1.000 |

Vessel perforation (n/N (%)) | 0/58 (0%) | 0/31 (0%) | 0/27 (0%) | 0%, N/A | 1.000 |

Major groin complication (n/N (%)) | 0/58 (0%) | 0/31 (0%) | 0/27 (0%) | 0%, N/A | 1.000 |

*Wilcoxon rank sum or Fisher’s exact test for difference between isolated M2 or M3 and LVO + M2 or M3 groups. Hodges-Lehmann estimate and CI was computed for results of Wilcoxon rank sum test. Exact estimate and Clopper-Pearson CI was computed for results of Fisher’s exact test.

ICH, intracranial hemorrhage; LVO, large vessel occlusion; mRS, modified Rankin Scale; mTICI, modified Thrombolysis in Cerebral Infarction; NIHSS, National Institutes of Health Stroke Scale; PI,Principal Investigator.