Table 1

Identified low NIHSS EVT literature

Date	Author	Investigation	N	NIHSS score	Vessel criteria	Primary outcome	Study conclusion
2020	Toth et al 41	EVT feasibility	20	≤5	Anterior and posterior M2, basilar	mRS ≤1	95% mTICI ≥2b 95% mRS ≤1 0% sICH, 5% SND
2016	Bhogal et al 42	EVT feasibility	41	≤5	M1 only	mTICI ≥2b	75% mRS ≤2 88% mTICI ≥2b 10% sICH
2018	Kaschner et al 43	EVT feasibility	30	≤5	M1 only	mRS ≤2	97% mTICI ≥2b 3% sICH
2017	Dargazanli et al 44	EVT feasibility	138	≤7	Anterior M2, ICA-T	mTICI ≥2b	mTICI ≥2b predictive of FI 81% mTICI ≥2b
2016	Pfaff et al 45	EVT feasibility	33	≤8	None	mTICI ≥2b	EVT is safe 78% mTICI ≥2b 6% sICH
2018	Bowen et al 46	EVT feasibility	72	≤8	None	mRS ≤2	EVT is safe 93% mTICI ≥2b 0% sICH
2014	Urra et al 4	EVT vs BMM	78	≤5	Anterior and posterior M2, A1, basilar, P1	mRS ≤1	NS
2018	Haussen et al 5	EVT vs BMM	118	≤5	Anterior and posterior M2, ACA, basilar	NIHSS shift	EVT benefit (p=0.03)
2018	Nagel et al 6	EVT vs BMM	300	≤5	Anterior and posterior M2, ACA, basilar	mRS ≤2	EVT benefit (p=0.03)
2019	†Goyal et al 3	EVT vs BMM	251	≤5	Anterior M2, ICA-T	mRS ≤2	NS
2017	Haussen et al 7	EVT vs BMM	32	≤5	Anterior M2, ICA-T	NIHSS shift	EVT benefit (p=0.04)
2018	Sarraj et al 8	EVT vs BMM	214	≤5	Anterior M4, ACA	mRS ≤1	NS
2020	Saito et al 9	EVT vs BMM	272	≤5	Anterior and posterior M3, A2, P2	mRS ≤2	NS
2020	Wolman et al 10	EVT vs BMM	47	≤6	Anterior-none	NIHSS shift	NS
2017	Dargazanli et al 11	EVT vs BMM	301	≤7	Anterior M2, ICA-T	mRS ≤1	NS
2019	†Shang et al 12	EVT vs BMM	177	≤8	Anterior M2, ACA	mRS ≤1	EVT benefit (p=0.008)
2019	Manno et al 47	EVT vs IVT	312	≤5	Anterior M2, ICA-T	mRS ≤1	NS
2017	Messer et al 48	EVT vs IVT	54	≤5	Anterior M2, ICA-T	mRS ≤1	NS
2018	Kastrup et al 49	EVT vs IVT	305	≤10	Anterior M2, ICA-T	mRS ≤2	NS
2020	Heldner et al 50	EVT vs IVT vs CM	185	≤5	Anterior M1, ICA-T	SND	EVT or IVT better than conservative
2018	Shang et al 51	Extended window	93	≤8	Anterior M2, ACA	mRS ≤1	NS
2019	Goldhoorn et al 26	Low vs high NIHSS score	71	≤5	Anterior M2, A2	mRS ≤2	Outcomes better patients within low NIHSS score
2019	Kaesmacher et al 52	Low vs high NIHSS score	193	≤7	Anterior and posterior M3, A2, P2	mRS ≤1	Safety/efficacy similar
2019	Asdaghi et al 21	Low vs high NIHSS score	446	≤5	None	Patient characteristics	–

*For vessel imaging criteria the most distal artery of the parent artery is listed. For example, if M4 is listed the study included MCA sections M1, M2, M3, and M4.
†Indicates study also conducted meta-analysis of literature.
ACA, anterior cerebral artery; BMM, best medical management; CM, conservative management; EVT, endovascular therapy; ICA-T, internal carotid artery-terminus; IVT, intravenous therapy; MCA, middle cerebral artery; mRS, mofified Rankin Scale; mTICI, modified Thrombolysis in Cerebral Infarction; N, number of patients; NS, no difference in primary outcome; sICH, symptomatic intracranial hemorrhage; SND, symptomatic neurological deficit.