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Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils

  • Interventional Neuroradiology
  • Published:
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Abstract

Introduction

It is claimed that bioactive coils induce accelerated and more durable aneurysm healing. Data supporting this claim are quite limited. Our purpose was to compare the angiographic and histological results obtained following treatment with different coil types.

Methods

Bifurcation type aneurysms were surgically created in 24 dogs and treated using standard clinical techniques. Eight were treated with Guglielmi detachable coils (GDC), eight with first-generation Matrix coils, and eight with a combination of GDC and Matrix coils. The aneurysms were explanted and final angiographic evaluations performed 12 weeks after treatment. Angiographic and histological outcomes were documented.

Results

Increased coil compaction with aneurysm recurrence was found in aneurysms treated with first-generation Matrix coils as compared to standard GDC (P = 0.0001). In aneurysms treated with first-generation Matrix coils thrombus organization was better than in those treated with either standard GDC coils (P = 0.008) or with a combination of GDC and Matrix coils (P = 0.04). In aneurysms treated with first-generation Matrix coils there were no endothelialized vascular clefts within the coil mass, but they were seen in the majority of aneurysms treated with GDC or a combination of GDC and Matrix coils (P = 0.003).

Conclusion

Aneurysms treated with first-generation Matrix coils showed the greatest degree of coil compaction and aneurysm recurrence on the final angiographic evaluation. Aneurysms treated with first-generation Matrix coils showed enhanced thrombus organization and absence of vascular clefts at the aneurysm neck that were markedly different from those treated with bare platinum coils or a combination of GDC and Matrix coils.

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Notes

  1. Panel comprised of physician consultants to Boston Scientific Neurovascular.

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Acknowledgements

The authors would like to acknowledge the significant contributions of Jennifer Powers and Al Rappe.

Conflict of interest statement

This research was supported by a grant from Boston Scientific Corporation. Drs. Turk and Strother are consultants for Boston Scientific Corporation. Victoria Carr-Brendel and Igor Polyakov are employees of Boston Scientific Corporation.

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Authors and Affiliations

  1. Department of Radiology, University of Wisconsin Hospital and Clinics, Madison, WI, USA

    Aquilla S. Turk, Dan Consigny, Julie Grinde & Charles M. Strother

  2. Department of Neurosurgery, University of Wisconsin Hospital and Clinics, 600 Highland Ave., Madison, WI, 53792, USA

    Aquilla S. Turk

  3. Department of Statistics, University of Wisconsin Hospital and Clinics, Madison, WI, USA

    Rajat Mukherjee

  4. University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

    Christopher M. Luty

  5. Neurovascular Division, Boston Scientific Corporation, Fremont, CA, USA

    Victoria Carr-Brendel & Igor Polyakov

Authors
  1. Aquilla S. Turk
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  2. Christopher M. Luty
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  3. Victoria Carr-Brendel
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  4. Igor Polyakov
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  5. Dan Consigny
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  8. Charles M. Strother
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Correspondence to Aquilla S. Turk.

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Turk, A.S., Luty, C.M., Carr-Brendel, V. et al. Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils. Neuroradiology 50, 57–65 (2008). https://doi.org/10.1007/s00234-007-0302-5

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  • DOI: https://doi.org/10.1007/s00234-007-0302-5

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