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Long-term results with Matrix coils vs. GDC: an angiographic and histopathological comparison

  • Interventional Neuroradiology
  • Published:
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Abstract

Introduction

The aim of the study was to compare standard platinum Guglielmi detachable coils (GDC) with coated platinum coils (Matrix; both Boston Scientific, Fremont, CA) regarding handling, complications, occlusion and recanalization rate after 3 and 6 months.

Methods

Aneurysms in the right common carotid artery were created in 25 rabbits. The animals were divided into five groups of five animals each. The animals of group 1 (the control group) received no treatment of the induced aneurysms, the animals of groups 2 and 3 (killed at 3 and 6 months) were treated with standard GDC, and the animals of groups 4 and 5 (killed at 3 and 6 months) were treated with Matrix coils.

Results

Histopathological evaluation showed organized thrombus formation and connective tissue with neovascularization around the implanted coils in all the treated groups. The achieved occlusion rates in groups 2 and 3 were identical to those in groups 4 and 5. Thus the long-term results of aneurysm treatment with GDC and Matrix coils show no differences regarding occlusion and recanalization rates. The only noticeable difference was the difference in handling. More force was required to pushing the Matrix coils forward through the microcatheter and there was more friction in coil interaction in the aneurysm.

Conclusion

The bioactive coating of the Matrix coil produces no significant benefit in achieving higher occlusion and lower recanalization rates, and the coil is more difficult to handle. Future bioactive coils must be shown to produce significantly better long-term results than GDC and their ease of handling has to be improved.

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References

  1. Grunwald IQ, Romeike BF, Roth C et al (2005) Anticoagulation regimes and their influence on the occlusion rate of aneurysms: an experimental study in rabbits. Neurosurgery 57(5):1048–1055

    Article  PubMed  Google Scholar 

  2. Ding YH, Dai D, Lewis DA et al (2005) Intra-venous digital subtraction angiography: an alternative method to intra-arterial digital subtraction angiography for experimental aneurysm imaging. Neuroradiology 47(10):792–795

    Article  PubMed  Google Scholar 

  3. Cognard C, Pierot L, Boulin A et al (1997) Intracranial aneurysms: endovascular treatment with mechanical detachable spirals in 60 aneurysms. Radiology 202(3):783–792

    PubMed  CAS  Google Scholar 

  4. Cognard C, Weill A, Castaings L et al (1998) Intracranial berry aneurysms: angiographic and clinical results after endovascular treatment. Radiology 206(2):499–510

    PubMed  CAS  Google Scholar 

  5. Cognard C, Weill A, Spelle L et al (1999) Long-term angiographic follow-up of 169 intracranial berry aneurysms occluded with detachable coils. Radiology 212(2):348–356

    PubMed  CAS  Google Scholar 

  6. Sluzewski M, van Rooij J, Slob MJ et al (2004) Relation between aneurysm volume, packing, and compaction in 145 cerebral aneurysms treated with coils. Radiology 231(3):653–658

    Article  PubMed  Google Scholar 

  7. Tamatani S, Ito Y, Abe H et al (2002) Evaluation of the stability of aneurysms after embolization using detachable coils: correlation between stability of aneurysms and embolized volume of aneurysms. AJNR Am J Neuroradiol 23(5):762–767

    PubMed  Google Scholar 

  8. Murayama Y, Viñuela S, Ishii A et al (2006) Initial clinical experience with matrix detachable coils for the treatment of intracranial aneurysms. J Neurosurg 105(2):192–199

    Article  PubMed  Google Scholar 

  9. Grunwald IQ, Papanagiotou P, Politi M et al (2006) Endovascular treatment of unruptured intracranial aneurysms: occurrence of thromboembolic events. Neurosurgery 58(4):612–618

    Article  PubMed  Google Scholar 

  10. Byrne JV, Sohn MJ, Molyneux AJ et al (1999) Five-year experience in using coil embolization for ruptured intracranial aneurysms: outcomes and incidence of late rebleeding. J Neurosurg 90(4):656–663

    Article  PubMed  CAS  Google Scholar 

  11. Grunwald IQ, Papanagiotou P, Struffert T et al (2007) Recanalization after endovascular treatment of intracerebral aneurysms. Neuroradiology 49(1):41–47

    Article  PubMed  Google Scholar 

  12. Katsaridis V, Papagiannaki C, Violaris C (2006) Guglielmi detachable coils versus matrix coils: a comparison of the immediate posttreatment results of the embolization of 364 cerebral aneurysms in 307 patients: a single-center, single-surgeon experience. AJNR Am J Neuroradiol 27(9):1841–1848

    PubMed  CAS  Google Scholar 

  13. Rossitti S (2007) Endovascular coiling of intracranial aneurysms using bioactive coils: a single-center study. Acta Radiol 48(5):565–576

    Article  PubMed  CAS  Google Scholar 

  14. Wong GK, Yu SC, Poon WS (2007) Clinical and angiographic outcome of intracranial aneurysms treated with Matrix detachable coils in Chinese patients. Surg Neurol 67(2):122–126

    Article  PubMed  Google Scholar 

  15. Taschner CA, Leclerc X, Rachdi H et al (2005) Matrix detachable coils for the endovascular treatment of intracranial aneurysms: analysis of early angiographic and clinical outcomes. Stroke 36(10):2176–2180

    Article  PubMed  Google Scholar 

  16. Murayama Y, Tateshima S, Gonzales NR et al (2003) Matrix and bioabsorbable polymeric coils accelerate healing of intracranial aneurysms: long-term experimental study. Stroke 34(8):2031–2037

    Article  PubMed  Google Scholar 

  17. Akiba Y, Murayama Y, Viñuela F et al (1999) Balloon-assisted Guglielmi detachable coiling of wide-necked aneurysms: Part I – experimental evaluation. Neurosurgery 45(3):519–527

    Article  PubMed  CAS  Google Scholar 

  18. Forrest MD, O’Reilly GV (1989) Production of experimental aneurysms at a surgically created arterial bifurcation. AJNR Am J Neuroradiol 10(2):400–402

    PubMed  CAS  Google Scholar 

  19. Kerber CW, Heilman CB (1992) Flow dynamics in the human carotid artery: I. Preliminary observations using a transparent elastic model. AJNR Am J Neuroradiol 13(1):173–180

    CAS  Google Scholar 

  20. Kerber CW, Liepsch D (1994) Flow dynamics for radiologists. II. Practical considerations in the live human. AJNR Am J Neuroradiol 15(6):1076–1086

    PubMed  CAS  Google Scholar 

  21. Kerber CW, Liepsch D (1994) Flow dynamics for radiologists. I. Basic principles of fluid flow. AJNR Am J Neuroradiol 15(6):1065–1075

    PubMed  CAS  Google Scholar 

  22. Song JK, Niimi Y, Yoshino Y et al (2007) Assessment of Matrix coils in a canine model of a large bifurcation aneurysm. Neuroradiology 49(3):231–235

    Article  PubMed  Google Scholar 

  23. Pierot L, Bonafé A, Bracard S et al (2006) Endovascular treatment of intracranial aneurysms with matrix detachable coils: immediate posttreatment results from a prospective multicenter registry. AJNR Am J Neuroradiol 27(8):1693–1699

    PubMed  CAS  Google Scholar 

  24. Kang HS, Han MH, Kwon BJ et al (2005) Short-term outcome of intracranial aneurysms treated with polyglycolic acid/lactide copolymer-coated coils compared to historical controls treated with bare platinum coils: a single-center experience. AJNR Am J Neuroradiol 26(8):1921–1928

    PubMed  Google Scholar 

  25. Linfante I, Akkawi NM, Perlow A et al (2005) Polyglycolide/polylactide-coated platinum coils for patients with ruptured and unruptured cerebral aneurysms: a single-center experience. Stroke 36(9):1948–1953

    Article  PubMed  Google Scholar 

  26. Carter LP, Guthkelch AN, Orozco J et al (1992) Influence of tissue plasminogen activator and heparin on cerebral ischemia in a rabbit model. Stroke 23(6):883–888

    PubMed  CAS  Google Scholar 

  27. Cloft HJ, Altes TA, Marx WF et al (1999) Endovascular creation of an in vivo bifurcation aneurysm model in rabbits. Radiology 213(1):223–228

    PubMed  CAS  Google Scholar 

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Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Diagnostic and Interventional Neuroradiology, University of the Saarland, Homburg, Germany

    C. Roth, I. Q. Grunwald, C. Krick, P. Papanagiotou, P. Krampe & W. Reith

  2. Department of Neuroradiology, University Hospital Erlangen, Erlangen, Germany

    T. Struffert

  3. Department of Neuropathology, Friedrich-Schiller University, Jena, Germany

    B. F. M. Romeike

  4. Department of Diagnostic and Interventional Neuroradiology, University Clinic of the Saarland, 66421, Homburg, Germany

    C. Roth

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  1. C. Roth
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  2. T. Struffert
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  3. I. Q. Grunwald
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  4. B. F. M. Romeike
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  5. C. Krick
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  6. P. Papanagiotou
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  7. P. Krampe
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  8. W. Reith
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Correspondence to C. Roth.

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Roth, C., Struffert, T., Grunwald, I.Q. et al. Long-term results with Matrix coils vs. GDC: an angiographic and histopathological comparison. Neuroradiology 50, 693–699 (2008). https://doi.org/10.1007/s00234-008-0392-8

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  • DOI: https://doi.org/10.1007/s00234-008-0392-8

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