Laboratory investigationHemolysis Comparison between the OmniSonics OmniWave Endovascular System and the Possis AngioJet in a Porcine Model
Section snippets
Procedure
Procedures were performed after receiving institutional IACUC approval in accordance with Good Laboratory Practices. The native-vessel nonthrombosed pig model was chosen because porcine weight, blood volume, and vessel diameters are comparable to that in adult humans. Twelve female Yorkshire swine with an average weight of 85.5 kg (range, 64.1–145 kg) were studied. Six were treated with the OmniWave device and six with the AngioJet connected to an Xpeedior-6 catheter (Possis). According to a
Baseline Characteristics
At baseline, animals in the OmniWave and AngioJet groups did not differ significantly from each other with regard to weight (P = .099), hematocrit level (P = .358), WBC count (P = .928), and platelet count (P = .250) (Table). Animals in the AngioJet group had a higher average baseline creatinine level (1.85 mg/dL ± 0.22 [163 μmol/L ± 19]) than those in the OmniWave group (1.53 mg/dL ± 0.18 [135 μmol/L ± 16]; P = .021), although all creatinine measurements were within the normal range for pigs
Discussion
The red cell membrane is composed of a metastable lipid bilayer. Shearing forces on the outer membrane can effect a transient opening of pores and, if they exceed a critical point, result in irreversible membrane rupture and lysis (17). Membrane deformation can be brought on by exposure to ultrasonic energy through the shearing forces of shock waves or flow effects from cavitation bubbles (as with the OmniWave) or shear stress from turbulent or steady flow through viscous and inertial fluid
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Risk factors for acute kidney injury after pharmacomechanical thrombolysis for acute deep vein thrombosis
2021, Journal of Vascular Surgery: Venous and Lymphatic DisordersCitation Excerpt :Careful consideration is required to not surpass a total thrombectomy volume of 300 mL in accordance with the instructions for use. Multiple studies have demonstrated hemolysis resulting from AngioJet therapy in animal models.7,8 This intravascular hemolysis results in acute tubular necrosis due to hemoglobinuria and, ultimately, AKI.
Endoluminal atherosclerotic plaque debulking using enzymatic and ultrasonic energy
2019, Journal of Surgical ResearchComparison of ASPIRE Mechanical Thrombectomy Versus AngioJet Thrombectomy System in a Porcine Iliac Vein Thrombosis Model
2017, Annals of Vascular SurgeryCitation Excerpt :In this report, we compared the device performance, including thrombectomy efficacy, thrombogenicity, hemolysis, and device-associated pulmonary embolism of the AngioJet thrombectomy system and ASPIRE thrombectomy device using a porcine DVT model. The AngioJet thrombectomy catheter received the Food and Drug Administration (FDA) approval for thrombectomy application in 1999, and its utility has been widely examined in both clinical literature and animal studies.7,11,18 This device requires a console unit to generate a high-velocity fluid stream, which is delivered to the catheter to achieve the thrombectomy functionality.
Hemodynamic and Hematologic Effects of Histotripsy of Free-Flowing Blood: Implications for Ultrasound-Mediated Thrombolysis
2015, Journal of Vascular and Interventional RadiologyCitation Excerpt :A previous study in pigs found peak free hemoglobin of 1,367 mg/dL after 10 minutes of AngioJet therapy (14). After 10 minutes of OmniWave therapy, peak free hemoglobin was 228 mg/dL (14). After 10 minutes of histotripsy in the present study, free hemoglobin was 156 mg/dL ± 58.4 in the surviving animals.
Utility of Thrombectomy in Primary Percutaneous Coronary Intervention
2013, Interventional Cardiology ClinicsCitation Excerpt :Recanalization, defined as TIMI flow 2 to 3 occurred in 89% of patients.49 Currently, FDA-approved for use in thrombotic dialysis shunts, the OmniWave Endovascular System (OmniSonics Medical Technologies, Wilmington, Massachusetts) is a novel system that emits low-energy (20 kHz) ultrasonic waves from the distal 10 cm of a 0.018-in wire, resulting in cavitation of thrombus with no disruption of underlying endothelium.50 This technology may warrant further investigation in certain patient subsets, such as those with high thrombus burden during acute MI, and may one day serve a role adjunctively in acute MI.
A systematic review of percutaneous mechanical thrombectomy in the treatment of deep venous thrombosis
2011, European Journal of Vascular and Endovascular Surgery
From the 2008 SIR annual meeting.
E.V.L., A.M.K, and R.B. are employees of OmniSonics Medical Technologies.
W.B. is a consultant for OmniSonics Medical Technologies. M.V. is an employee of DaVinci Biomedical.