Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models

AL Papa, A Jiang, N Korin, MB Chen… - Science translational …, 2019 - science.org
Platelets are crucial for normal hemostasis; however, their hyperactivation also contributes
to many potentially lethal pathologies including myocardial infarction, stroke, and cancer …

Quantitative assessment of device–clot interaction for stent retriever thrombectomy

K van der Marel, JY Chueh, OW Brooks… - Journal of …, 2016 - jnis.bmj.com
Purpose Rapid revascularization in emergent large vessel occlusion with endovascular
embolectomy has proven clinical benefit. We sought to measure device–clot interaction as a …

Acute thrombus formation on phosphorilcholine surface modified flow diverters

M Marosfoi, F Clarencon, ET Langan… - Journal of …, 2018 - jnis.bmj.com
Purpose Thromboembolic complications remain a limitation of flow diverting stents. We
hypothesize that phosphorilcholine surface modified flow diverters (Pipeline Flex with Shield …

[HTML][HTML] A neurovascular high-frequency optical coherence tomography system enables in situ cerebrovascular volumetric microscopy

GJ Ughi, MG Marosfoi, RM King, J Caroff… - Nature …, 2020 - nature.com
Intravascular imaging has emerged as a valuable tool for the treatment of coronary and
peripheral artery disease; however, no solution is available for safe and reliable use in the …

Communicating malapposition of flow diverters assessed with optical coherence tomography correlates with delayed aneurysm occlusion

RM King, OW Brooks, ET Langan, J Caroff… - Journal of …, 2018 - jnis.bmj.com
Background Optical coherence tomography (OCT) is a high resolution intravascular imaging
method that allows visualization of flow diverter struts and the vessel wall. In this study …

Shear-activated nanoparticle aggregates combined with temporary endovascular bypass to treat large vessel occlusion

MG Marosfoi, N Korin, MJ Gounis, O Uzun… - Stroke, 2015 - Am Heart Assoc
Background and Purpose—The goal of this study is to combine temporary endovascular
bypass (TEB) with a novel shear-activated nanotherapeutic (SA-NT) that releases …

Phosphorylcholine surface modified flow diverter associated with reduced intimal hyperplasia

J Caroff, T Tamura, RM King, PN Lylyk… - Journal of …, 2018 - jnis.bmj.com
Background Optical coherence tomography (OCT) is a high-resolution, intra-vascular
diagnostic technique widely used for the characterization of vascular pathologies and …

In situ tissue engineering: endothelial growth patterns as a function of flow diverter design

M Marosfoi, ET Langan, L Strittmatter… - Journal of …, 2017 - jnis.bmj.com
Background Vascular remodeling in response to implantation of a tissue engineering
scaffold such as a flow diverter (FD) leads to the cure of intracranial aneurysms. We …

Microcatheter navigation through the clot: does size matter?

J Caroff, RM King, R Arslanian, M Marosfoi… - Journal of …, 2019 - jnis.bmj.com
Background Despite high recanalization rates achieved with endovascular treatment of
acute ischemic strokes, around 50% of eligible patients will not achieve a good outcome …

Acute thrombus burden on coated flow diverters assessed by high frequency optical coherence tomography

RM King, ET Langan, GJ Ughi, CM Raskett… - Cardiovascular and …, 2020 - Springer
Purpose The implantation of flow diverters requires administration of dual anti-platelet
therapy, posing the potential for complications. The p48MW HPC (phenox, Bochüm …