Neural stem cells (NSCs) are capable of tracking migrating glioma cells. To exploit this
tropism to generate an antitumor T-cell response, particularly against disseminating tumor …

Current therapies for gliomas fail to address their highly infiltrative nature. Standard
treatments oftenleave behind microscopic neoplastic reservoirs, resulting in eventual tumor …

Glioblastoma multiforme is a highly invasive tumor bearing a dismal prognosis.
Experimental strategies that focus on the specific biological cues governing the invasive …

Abstract PGE 2, synthesized by cyclooxygenase-2 (COX-2)-overexpressing tumor, is known
to contribute to cellular immune suppression in cancer patients, but the mechanism remains …

Increasing evidence points to a fundamental role for cancer stem cells (CSC) in the initiation
and propagation of many tumors. As such, in the context of glioblastoma multiforme (GBM) …

We have developed a method for integrating three dimensional–volume reconstructions of
spatially resolved matrix-assisted laser desorption/ionization imaging mass spectrometry …

Malignant gliomas spawn disseminated microsatellites, which are largely refractory to
currently employed therapies, resulting in eventual tumor recurrence and death. The use of …

Theefficient and large-scale generation of neural progenitor cells for neural grafting in the
treatmentof neurological diseases has been a challenge. Here we describe the isolation and …

CXCR4, a cell surface chemokine receptor, mediates cellular dissemination, invasion, and
proliferation in a wide range of cancers including gliomas. It is over-expressed in glioma …

OBJECTIVE With the objective of investigating the utility of CXCR4, a chemokine receptor
known to mediate glioma cell invasiveness, as a molecular marker for peritumoral disease …