From tau to toxicity: emerging roles of NMDA receptor in Alzheimer's disease

MO Chohan, K Iqbal - Journal of Alzheimer's Disease, 2006 - content.iospress.com
Glutamate toxicity through NMDA receptor channels has long been central to the
understanding of acute neuronal injury. Recent studies implicate similar events in chronic …

5-Aminolevulinic acid fluorescence guided surgery for recurrent high-grade gliomas

MO Chohan, MS Berger - Journal of Neuro-Oncology, 2019 - Springer
Introduction Fluorescence guided surgery (FGS) with five-aminolevulinic acid (5-ALA) is
expected to revolutionize neurosurgical care of patients with high-grade gliomas (HGG) …

[HTML][HTML] Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau

B Li, MO Chohan, I Grundke-Iqbal, K Iqbal - Acta neuropathologica, 2007 - Springer
Hyperphosphorylated tau has long been proposed as the key molecule disrupting normal
neuronal microtubule dynamics and leading to neurofibrillary degeneration in Alzheimer …

[HTML][HTML] Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome*♦

J Shi, T Zhang, C Zhou, MO Chohan, X Gu… - Journal of Biological …, 2008 - ASBMB
Two groups of tau, 3R-and 4R-tau, are generated by alternative splicing of tau exon 10.
Normal adult human brain expresses equal levels of them. Disruption of the physiological …

[HTML][HTML] Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine

MO Chohan, S Khatoon, IG Iqbal, K Iqbal - FEBS letters, 2006 - Elsevier
The activity of protein phosphatase (PP)-2A, which regulates tau phosphorylation, is
compromised in Alzheimer disease brain. Here we show that the transient transfection of …

Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide

MO Chohan, B Li, J Blanchard, YC Tung… - Neurobiology of …, 2011 - Elsevier
Pharmacological enhancement of hippocampal neurogenesis is a therapeutic approach for
improvement of cognition in learning and memory disorders such as Alzheimer's disease …

Three-dimensional volumetric measurements in defining endoscope-guided giant adenoma surgery outcomes

MO Chohan, AM Levin, R Singh, Z Zhou, CL Green… - Pituitary, 2016 - Springer
Purpose Maximum two-dimensional (2D) diameter has been used to define giant pituitary
adenoma (GPA) surgery outcomes as has volume using an ellipsoid approximation of …

[HTML][HTML] Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice

B Li, L Wanka, J Blanchard, F Liu, MO Chohan, K Iqbal… - FEBS letters, 2010 - Elsevier
Development of neurotrophic peptidergic drugs that can mimic neurotrophins and promote
neurogenesis and maturation of newborn cells into mature functional neurons represents an …

Metastatic epithelioid trophoblastic tumor involving the spine

MO Chohan, T Rehman, LA Cerilli, K Devers… - Spine, 2010 - journals.lww.com
Study Design. This is a single case-based report. Objective. We report the first case of
epithelioid trophoblastic tumor (ETT) presenting as primary metastasis to the spine …

Beneficial effect of a CNTF tetrapeptide on adult hippocampal neurogenesis, neuronal plasticity, and spatial memory in mice

J Blanchard, MO Chohan, B Li, F Liu… - Journal of …, 2010 - content.iospress.com
A therapeutic strategy against cognitive disorders like Alzheimer's disease is to take
advantage of the regenerative ability of the brain and the properties of neurotrophic factors …