Glioblastomas (GBM) are the most common and aggressive tumors of the central nervous
system. Rapid tumor growth and diffuse infiltration into healthy brain tissue, along with high …

Object Arachnoid cysts are a frequent finding on intracranial imaging in children. The
prevalence and natural history of these cysts are not well defined. The authors studied a …

Object Arachnoid cysts are a frequent finding on intracranial imaging. The prevalence and
natural history of these cysts in adults are not well defined. Methods We retrospectively …

Object This study was undertaken to define the age-related prevalence of cavernous
malformations (CMs) in children and young adults undergoing intracranial imaging. In …

Intra-tumoral heterogeneity is a hallmark of glioblastoma that challenges treatment efficacy.
However, the mechanisms that set up tumor heterogeneity and tumor cell migration remain …

Object The objective of this study was to compare the accuracy of 3 methods of ventricular
catheter placement during CSF shunt operations: the freehand technique using surface …

Mutant isocitrate-dehydrogenase 1 (mIDH1) synthesizes the oncometabolite 2-
hydroxyglutarate (2HG), which elicits epigenetic reprogramming of the glioma cells' …

Glioblastoma, the deadliest form of primary brain tumor, remains a disease without cure.
Treatment resistance is in large part attributed to limitations in the delivery and distribution of …

Object We reviewed our experience with pineal cysts to define the natural history and
clinical relevance of this common intracranial finding. Methods The study population …

Object Pineal cysts are a frequent incidental finding on intracranial imaging. In adults, the
prevalence of pineal cysts is estimated to be 1.1–4.3%. However, the prevalence is not well …