Article Text

Download PDFPDF
Original research
Elevated mean platelet volume is associated with poor outcome after mechanical thrombectomy
  1. Feng Peng1,2,
  2. Weihong Zheng2,
  3. Fengli Li3,
  4. Jinjing Wang3,
  5. Zhaoji Liu2,
  6. Xingyu Chen2,
  7. Lulu Xiao1,3,
  8. Wen Sun1,3,
  9. Xinfeng Liu1,3
  1. 1Department of Neurology, Jinling Hospital, Nanjing Medical University, Nanjing, China
  2. 2Department of Neurology, Zhongshan Hospital Xiamen University, Xiamen, China
  3. 3Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
  1. Correspondence to Dr Wen Sun and Prof Xinfeng Liu, Department of Neurology, Jinling Hospital, Nanjing Medical University, 305 East Zhongshan Rd, Nanjing 210002, Jiangsu Province, China; sunwen_neuro11{at} and


Background Elevated mean platelet volume (MPV), indicating higher platelet activity, could be a predictor of prognosis in patients with acute ischemic stroke receiving medical therapy.

Objective To investigate the relationship between MPV and functional outcome in patients with acute anterior circulation stroke 3 months after undergoing mechanical thrombectomy (MT).

Methods A total of 153 consecutive patients with acute stroke following MT, in two separate stroke centers, were enrolled between May 2013 and March 2016. MPV was measured on admission. Subjects were divided into two groups according to average MPV level. Univariate and multivariate analyses were performed. MPV was also incorporated into the Houston IA Therapy (HIAT) score, which was developed as a scoring system to predict poor prognosis, and the prediction capability was compared with the HIAT score alone.

Results The average MPV was 10.4 fL. Patients with high MPV had a significantly lower rate of functional independence (28.9% vs 57.1%, p=0.000). After multivariable analysis, elevated MPV remained an independent predictor of unfavorable outcome (OR=3.93, 95% CI 1.73 to 8.94, p=0.001). When the MPV cut-off value was set at 10.4 fL using the receiver operating characteristic (ROC) analysis, MPV ≥10.4 fL predicted unfavorable outcome with 62.1% sensitivity and 66.7% specificity, respectively. Addition of MPV to the HIAT score did not improve predictive power compared with the HIAT score system alone by a comparison of the areas under the two ROC curves (0.70 vs 0.62, p=0.174).

Conclusions Elevated MPV is an independent predictor of poor outcome in patients with acute anterior circulation stroke undergoing MT at 3 months.

  • Intervention
  • Atherosclerosis

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • FP and WZ contributed equally and are co-first authors.

  • Contributors FP: study design, acquired and analyzed the data, and manuscript drafting. WZ, FL: study design. JW: data collection and statistical analysis. ZL, XC: data collection. LX: revised the draft paper. WS: study design and critical revision of manuscript. XL: study design and revision of draft paper.

  • Funding This work was supported by the National Natural Science Foundation of China. Grant numbers (81501193 and 81530038).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Ethics committees of the Jinling Hospital, Nanjing Medical University and Zhongshan Hospital Xiamen University.

  • Provenance and peer review Not commissioned; externally peer reviewed.