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Original research
Anterior cerebral artery embolism during thrombectomy increases disability and mortality
  1. Vanessa Chalumeau1,
  2. Raphaël Blanc1,
  3. Hocine Redjem1,
  4. Gabriele Ciccio1,
  5. Stanislas Smajda1,
  6. Jean-Philippe Desilles1,
  7. Daniele Botta1,
  8. Simon Escalard1,
  9. William Boisseau1,
  10. Benjamin Maïer1,
  11. Julien Labreuche2,
  12. Mickaël Obadia3,
  13. Michel Piotin1,
  14. Mikael Mazighi1,4,5,6
  1. 1 Departement of Interventional Neuroradiology, Rothschild Foundation, Paris, France
  2. 2 Department of Biostatistics, Hospital Center Regional University De Lille, University of Lille, Paris, France
  3. 3 Department of Neurology, Rothschild Foundation, Paris, France
  4. 4 Denis Diderot University, Paris, France
  5. 5 INSERM U 1148, Laboratory of Vascular Translational Science, Bichat Hospital, Paris, France
  6. 6 DHU Neurovasc, Paris, France
  1. Correspondence to Dr Vanessa Chalumeau, Service de Neuroradiologie Interventionnelle Fondation, ophtalmologique Adolphe de Rothschild, Paris 75019, France; chalumeau.vanessa{at}


Objective During thrombectomy, thromboembolic migration in previously unaffected territory may occur and is not systematically notified. We report our data on the incidence, predictors, and clinical outcome of anterior cerebral artery emboli (ACAE).

Methods From a prospectively collected thrombectomy database of consecutive patients with anterior circulation stroke between January 2012 and December 2016, 690 angiographic images were analyzed to assess ACAE. The primary outcome was a favorable outcome, defined as a 3 month modified Rankin Scale score of 0–2 or equal to the pre-stroke score.

Results ACAE occurred in 65 patients (9.4%; 95% CI 7.2% to 11.6%). Internal carotid artery occlusion (tandem or terminal), Alberta Stroke Program Early CT Score <7, increasing number of passes, and use of stent retriever alone (compared with distal aspiration alone or combined with stent retriever) were found to be independent predictors of ACAE. Compared with patients without ACAE, patients with ACAE had lower rates, with an adjusted OR (95% CI) of 0.48 (0.25 to 0.92; P=0.027) for favorable outcome and 0.49 (0.25 to 0.96; P=0.038) for early neurologic improvement. ACAE was significantly associated with a higher mortality (adjusted OR 1.93; 95% CI 1.03 to 3.61; P=0.039) and intracranial hemorrhagic complications (adjusted OR 2.45; 95% CI 1.33 to 4.47; P=0.004). Despite a successful reperfusion modified Thrombolysis in Cerebral Infarction score of 2b–3 at the end of the procedure, a favorable outcome was reached in 30% of patients with ACAE compared with 52.4% in the other patients (OR 0.39; 95% CI 0.19 to 0.78; P=0.008).

Conclusions Procedural ACAE was not an uncommon condition, and was associated with increased mortality and disability rates, regardless of the success of reperfusion.

  • stroke
  • thrombectomy
  • complications
  • embolic
  • angiography

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  • Contributors VC: study concept and design, acquisition of the data, and interpretation of the data. RB, MP, and MM: study concept and design, acquisition of the data, interpretation of the data, study supervision, and critical revision of manuscript for intellectual content. HR, GC, SS, J-PD, DB, SE, WB, BM, and MO: acquisition of the data. JL: statistical analysis, interpretation of the data, and study supervision.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial, or not-for-profit sectors.

  • Competing interests RB and MP received institutional grants from Stryker, Medtronic, Microvention, and Balt. They are proctors for Medtronic Pipeline Cases. MM has been a consultant for Servier, Acticor, Boerhinger, and Medtroni.

  • Patient consent Not required.

  • Ethics approval The study was approved by the local ethics committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.