Background and purpose Thrombectomy has become the standard of care for acute ischaemic stroke due to large vessel occlusion. Aim of this study was to compare the radiological outcomes and time metrics of the various thrombectomy techniques.
Methods In this retrospective, multicenter study we analysed the data of 450 patients with occlusion of the anterior circulation, treated in five high-volume center from 2013 to 2016. The treatment techniques were divided in three categories: first-pass use of a large-bore aspiration-catheter; first-pass use of a stent-retriever; and primary combined approach (PCA) of an aspiration-catheter and stent-retriever. Primary endpoints were successful reperfusion and groin to reperfusion time. Secondary endpoints were the number of attempts and occurrence of emboli in new territory (ENT). The primary analysis was based on the intention to treat groups (ITT).
Results The ITT-analysis showed significantly higher reperfusion rates, with 86% of successful reperfusion in the PCA-group compared with 73% in the aspiration group and 65% in the stent-retriever group. There was no significant difference in groin to reperfusion time regarding the used technique. The secondary analysis showed an impact of the technique on the number of attempts and the occurrence of ENTs. Lowest ENT rates and attempts were reported with the combined approach.
Conclusions The combined first-pass deployment of a stent-retriever and an aspiration-catheter was the most effective technique for reperfusion of anterior circulation large vessel occlusion. Our results correlate with the latest single-centrere studies, reporting very high reperfusion rates with PCA variations.
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Contributors Conception and design: ACH, M-NP. Analysis and interpretation of data: ACH, M-NP, DB, AK, AZ, NGH, IF, IM, JL, IT. Drafting of the manuscript: ACH, M-NP, J-HB, JT, JF, AM, PS, AB. Statistics: ACH, M-NP, AZ. Critically revising and approval of the manuscript: all authors.
Competing interests Jens Fiehler has received fees as consultant or lecturer from Acandis, Bayer, Boehringer-Ingelheim, Codman, Covidien,Medtronic, MicroVention, Penumbra, Philips, Sequent, Siemens and Stryker. Lectures for Boehringer-Ingelheim, Covidien, and Penumbra. Funding to institution: Medtronic, MicroVention. Funding to Institution: DFG, EU, BMBF,BMWi. Jan-Hendrik Buhk has received fees as consultant orlecturer from Acandis, Bayer, Codman, Medtronic, MicroVention, Philips and Stryker.Michael Knauth has received fees as consultant or lecturer from Siemens, Penumbra, Stryker, Acandis, Bayer.Marios-Nikos Psychogios has received fees as consultant or lecturer from Siemens, Penumbra, Stryker.
Ethics approval Ethics committee University Medical Centre Goettingen.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement Yes, we are willing to provide additional data upon request.