Objective We report the CSF opening pressure measurements obtained before and after venous sinus stenting in 50 patients with Idiopathic Intracranial Hypertension.
Methods The CSF opening pressure was measured with a spinal tap 3 months before and 3 months after treatment. All data was prospectively collected and included patient demographics, weight (kg), body-mass index (BMI), acetazolamide daily dosage (mg), procedural details, complications, venous sinus pressures (mm Hg), trans-stenotic pressure gradient (mm Hg), transverse sinus symmetry, and type of venous sinus stenosis.
Results The average pre-treatment CSF-OP was 37 cm water (range: 25–77) and the average post-treatment CSF-OP pressure was 20.2 cm water (range: 10–36), with an average reduction of 16.8 cm water (p<0.01). The post-treatment CSF-OP was less than 25 cm water in 40/50 patients. The average acetazolamide daily dose decreased from 950 mg to 300 mg the time of three-month follow-up (p<0.01). No patient required an increase in acetazolamide dose 3 months after VSS. The average weight before treatment was 95.4 kg with an average BMI of 35.41. There was an average increase in body weight of 1.1 kg at the three-month follow-up with average increase in BMI of 0.35 (p=0.03).
Conclusions In summary, we provided evidence that there is significant decrease in CSF-OP pressure in IIH patients 3 months after VSS, independent of acetazolamide usage or weight loss.
Disclosures A. Patsalides: None. C. Oliveira: None. M. Dinkin: None.
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