Background and purpose Computational fluid dynamics (CFD) can be used to evaluate hemodynamic factors related to aneurysm growth and rupture, however, limitations such as unknown patient-specific inlet boundary conditions exist. The dynamic information combined with the high spatial resolution of 4D-CTA allows quantification of blood flow rate and extraction of the vascular anatomy.

Materials and methods Slight adaptation of the 4D-CTA clinical protocol and optimized post-processing were tested in a pilot study including 6 patients. Blood flow was assessed in both internal carotid (ICAs) and vertebral (VAs) arteries of each patient by analyzing the temporal shift of full time-intensity curves (TICs).

Results We showed large inter-patient variability of the TIC shapes from which blood flow rates could be successfully measured in all patients and investigated vessels. On average, measured flow rates were 3.2±0.7 ml/s in the ICAs and 1.3±0.8 ml/s in the VAs, consistent with reference standards.

Conclusion This pilot study shows the high potential of using 4D-CTA to calculate patient-specific flow rates, in addition to extracting the anatomical geometries for CFD. The large variety of TICs shape highlights the importance of an adaptive TICs analysis as proposed in the present work. In-vitro validations and inter-modality comparisons are required to confirm these results.

Disclosures N. Cancelliere: None. P. Bouillot: None. O. Brina: None. K. Lovblad: None. T. Krings: None. D. Steinman: None. V. Mendes Pereira: None.