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E-065 MRA vs DSA in the follow-up imaging of endovascularly treated intracranial aneurysms, a meta analysis
  1. S Ahmed1,
  2. X Zheng2,
  3. M Kelly1,
  4. J Mocco2,
  5. R De Leacy2
  1. 1Neurosurgery, University of Saskatchewan, Saskatoon, SK, Canada
  2. 2Neurosurgery, Mount Sinai Hospital, New York, NY


Introduction Endovascular treatment of intracranial aneurysms has evolved significantly, and includes coil occlusion, with or without stent-assistance, as well as parent-vessel reconstruction using flow-diverting stents. Treated aneurysms must be followed over time to ensure durable occlusion, as more than 20% of endovascularly treated aneurysms have recurrence, with up to 9% requiring re-treatment.

While digital subtraction angiography (DSA) remains the gold standard, magnetic resonance angiography (MRA) has been utilized in the follow-up of endovascularly treated cerebral aneurysms as it is a non-invasive technique. Two different MRA techniques have traditionally been utilized: time-of-flight (TOF), and contrast-enhanced (CE) MRA.

We systematically reviewed the literature comparing MRA techniques to DSA for the follow-up of aneurysms undergoing endovascular treatment.

Methods Comprehensive searches utilizing the Embase, PubMed, and Cochrane databases were performed, and updated to December, 2017. Acquired studies were screened for appropriateness for inclusion in the meta-analysis. We included studies that compared an MRA technique with DSA for follow-up of aneurysms treated with endovascular means, and provided sufficient data for comparative evaluation of occlusion status. Studies were graded on methodological quality using the GRADE criteria.

Data were analysed using the Meta-DiSc software. Pooled sensitivity and specificity, with 95% confidence intervals (CI) were calculated using aneurysm occlusion status as defined by the Raymond-Roy occlusion grading scale. Aneurysms were classified as either being occluded, having residual neck filling, or residual dome filling. Subgroup analyses for study design (prospective vs retrospective), study quality (GRADE assessment), type of treatment, DSA technique, and MRI magnet strength, were performed.

Results The literature search yielded 1575 unique titles. Seventy-five titles were included in a full-text review, and after application of inclusion criteria, 40 studies were included in the meta-analysis. The GRADE assessment showed that the studies were of a good quality overall, with 22 studies (54%) scoring 4, 15 (37%) scoring 3, 3 (7%) scoring 2, while 1 (2%) study scored 1.

For TOF-MRA, sensitivity and specificity of all aneurysms undergoing endovascular therapy were 0.89 (95% CI: 0.86–0.9) and 0.94 (0.93–0.95), respectively. For CE-MRA, the sensitivity and specificity were 0.91 (0.88–0.94) and 0.96 (0.94–0.97), respectively. Treatment modality subgroup analysis was performed using a coiling group and a group containing all studies with intracranial stent use. For aneurysms with intracranial stent placement, sensitivity and specificity were 0.92 and 0.98 respectively for TOF-MRA, and 0.94 and 0.99 for CE-MRA.

Retrospective studies had higher sensitivity and specificity when compared to prospective studies (TOF: 0.93/0.97 vs 0.83/0.92; CE: 0.93/0.99 vs 0.87/0.92, respectively).

Subgroup analyses did not reveal significant differences in the sensitivity and specificity of MRA techniques with respect to 2D vs 3D DSA, or MRA magnet strength.

Conclusions MRA remains a reliable modality for the follow-up of aneurysms treated using endovascular means. Adjunctive use of intracranial stents does not significantly impede the diagnostic reliability of MRA techniques for detection of residual aneurysms. While most aneurysms can safely be followed using MRA techniques, patient and aneurysm-specific factors must be taken into account when planning follow-up for treated intracranial aneurysms.

Disclosures S. Ahmed: None. X. Zheng: None. M. Kelly: 2; C; Penumbra, Medtronic. J. Mocco: 2; C; Rebound Medical, Endostream, Synchron, Cerebrotech. 4; C; Apama, The Stroke Project, Endostream, Synchron, Cerebrotech, NeurVana, NeuroTechnology Investors. R. De Leacy: 1; C; Asahi Intec, Medtronic. 2; C; Penumbra, Siemens.

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