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Original research
Wide-neck bifurcation aneurysms of the middle cerebral artery and basilar apex treated by endovascular techniques: a multicentre, core lab adjudicated study evaluating safety and durability of occlusion (BRANCH)
  1. Reade A De Leacy1,
  2. Kyle M Fargen2,
  3. Justin R Mascitelli1,
  4. Johanna Fifi1,
  5. Lena Turkheimer1,
  6. Xiangnan Zhang1,
  7. Aman B Patel3,
  8. Matthew J Koch3,
  9. Aditya S Pandey4,
  10. D Andrew Wilkinson4,
  11. Julius Griauzde4,
  12. Robert F James5,
  13. Enzo M Fortuny5,
  14. Aurora Cruz5,
  15. Alan Boulos6,
  16. Emad Nourollah-Zadeh6,
  17. Alexandra Paul6,
  18. Eric Sauvageau7,
  19. Ricardo Hanel7,
  20. Pedro Aguilar-Salinas7,
  21. Roberta L Novakovic8,
  22. Babu G Welch8,
  23. Ranyah Almardawi9,
  24. Gaurav Jindal9,
  25. Harish Shownkeen10,
  26. Elad I Levy11,
  27. Adnan H Siddiqui11,
  28. J Mocco1
  1. 1 Department of Neurosurgery, Mount Sinai Hospital, New York City, New York, USA
  2. 2 Department of Neurological Surgery, Wake Forest University, Winston-Salem, North Carolina, USA
  3. 3 Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA
  4. 4 Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA
  5. 5 Department of Neurosurgery, University of Louisville, Louisville, Kentucky, USA
  6. 6 Department of Neurosurgery, Albany Medical Center, Albany, New York, USA
  7. 7 Department of Neurosurgery, Lyerly Baptist, Jacksonville, Florida, USA
  8. 8 Department of Neurosurgery, UT Southwestern Medical Center, Dallas, Texas, USA
  9. 9 Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Maryland, USA
  10. 10 Neurointerventional Surgery, Northwestern Medicine at Central DuPage Hospital, Winfield, Illinois, USA
  11. 11 Department of Neurosurgery, University at Buffalo, Buffalo, New York, USA
  1. Correspondence to Dr Reade A De Leacy, Department of Neurosurgery, Mount Sinai Hospital, New York City, NY 10029, USA; reade.deleacy{at}mountsinai.org

Abstract

Background and purpose BRANCH (wide-neck bifurcation aneurysms of the middle cerebral artery and basilar apex treated by endovascular techniques) is a multicentre, retrospective study comparing core lab evaluation of angiographic outcomes with self-reported outcomes.

Materials and methods Consecutive patients were enrolled from 10 US centres, aged between 18 and 85 with unruptured wide-neck middle cerebral artery (MCA) or basilar apex aneurysms treated endovascularly. Patient demographics, aneurysm morphology, procedural information, mortality and morbidity data and core lab and self-reported modified Raymond Roy (RR) outcomes were obtained.

Results 115 patients met inclusion criteria. Intervention-related mortality and significant morbidity rates were 1.7% (2/115) and 5.8% (6/103) respectively. Core lab adjudicated RR1 and 2 occlusion rates at follow-up were 30.6% and 32.4% respectively. The retreatment rate within the follow-up window was 10/115 (8.7%) and in stent stenosis at follow-up was 5/63 (7.9%). Self-reporting shows a statistically significant direction to angiographic RR one outcomes at follow-up compared with core lab evaluation, with OR 1.75 (95% CI 1.08 to 2.83).

Conclusion Endovascular treatment of wide-neck MCA and basilar apex aneurysms resulted in a core lab adjudicated RR1 occlusion rate of 30.6%. Self-reported results at follow-up favour better angiographic outcomes, with OR 1.75 (95% CI 1.08 to 2.83). These data demonstrate the need for novel endovascular devices specifically designed to treat complex intracranial aneurysms, as well as the importance of core lab adjudication in assessing outcomes in such a trial.

  • aneurysm
  • stent
  • balloon
  • coil
  • intervention
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Introduction

The endovascular treatment of both ruptured and unruptured intracranial aneurysms has become first-line management since the publication of the International Subarachnoid Aneurysm Trial (ISAT) results in 2002.1 However, until recently, wide-necked bifurcation aneurysms have classically been considered poor candidates for endovascular therapy. Standard coiling techniques are limited in their effectiveness at occluding these challenging types of aneurysms, with high recanalisation rates and the risk of parent vessel coil protrusion with potential thromboembolic consequences.

However, advances in endovascular techniques such as balloon-assisted coiling (BAC) and stent-assisted coiling (SAC) have allowed such aneurysms to be considered candidates for endovascular treatment.2–6 The inherent technical challenges associated with endovascular treatment of this subgroup of aneurysms has led to the ongoing development of wide-neck aneurysm specific bridging devices, intrasaccular flow disruption devices and the off-label use of flow diversion.7 However, at the time of writing this paper, these devices are not widely available for use in the United States.

Currently published data specifically evaluating the endovascular treatment of wide-necked bifurcating type aneurysms are derived from retrospective series using self-reported and not core lab adjudicated angiographic outcomes. The current literature demonstrates that retrospective non-independently evaluated studies consistently overestimate the treatment benefit and underestimate complication rates.8 We present a retrospective, multicentre, core lab adjudicated series of wide-neck bifurcating type aneurysms of the basilar apex and middle cerebral artery (MCA) bifurcation using on-label, FDA-approved devices evaluating durability of occlusion and safety, and investigating any discrepancy between self-reported and core lab outcomes.

Patients and methods

Ten US centres provided retrospective, de-identified data on up to a maximum of 15 consecutive patients per site, who underwent endovascular treatment of unruptured wide-neck bifurcation type MCA or basilar apex aneurysms using FDA-approved devices up to January 2017. A total of 88.8% of enrolled patients underwent treatment between January 2012 and January 2017. The first aneurysm treatment took place in May 2005. Aneurysms were considered wide necked if the longest neck dimension was between 4 and 8 mm inclusive or if the dome to neck ratio was ≤2.0.

All centres obtained institutional review board approval prior to data submission to the primary centre. Procedural technique and perioperative management including anti-aggregate therapy were non-standardized and based on standard of care at the individual treating centre. Consecutive patients with clinical and angiographic follow-up available 6–18 months after the index procedure were included.

Patient demographics, aneurysm and procedural details and self-reported outcomes

Patient demographics including patient age, sex, ethnicity/race and pertinent past medical history were collected. Aneurysm and angiographic details including aneurysm size, shape, neck dimension, dome to neck ratio, location, treatment method (unassisted, BAC or SAC), type of stent used and self-reported initial and follow-up angiographic occlusion (assessed using the modified Raymond Roy scale) were provided by each institution.9 Intra-procedural and post-procedural complication rates and types were reported for each patient, in addition to patient baseline and follow-up modified Rankin scale (mRS) data.

Core lab evaluation

The core lab consisted of an experienced neurointerventionalist (KF) from a non-enrolling site blinded both to patient and site identifiers. De-identified digital subtraction angiographic images were uploaded to a secure database by each site for evaluation by the imaging core lab. Pre and immediate post treatment standard anterioposterior and lateral whole head and magnified biplane working projection images were provided for evaluation. For follow-up imaging, either digital subtraction angiographic images or high-quality magnetic resonance angiography (MRA) images were uploaded as determined by the standard of care of the submitting sites. MRA follow-up was permitted due to its reported accuracy in the detection of recanalisation in coiled aneurysms.10 The core lab evaluated aneurysm occlusion using the modified Raymond Roy scale and the presence of in stent stenosis at follow-up.

Statistical evaluation

Descriptive statistical analysis results were summarised and presented using means with SD and frequencies with percentages for continuous and categorical variables respectively; t test and Fisher’s exact test were conducted for comparison. A P-value<0.05 was considered statistically significant, all tests were two sided if not stated otherwise. Shift analysis was performed by using a logistic proportional OR model. The categorical and ordinal analysis results for group comparison were evaluated and interpreted with odds ratios and corresponding 95% confidence intervals. All statistical analyses were performed and testified byR software (Version 3.4.1) and SAS software (Statistical Analysis Software, Version 9.4)

Results

Participants and procedural details

A total of 115 patients from 10 centres fulfilled criteria for enrollment. Patient demographic and clinical data are presented in table 1 and aneurysm morphological data in table 2. Patient mean age was 61.0 years (SD ±11.63). Twenty-six percent of patients were men (30/115). Forty-six aneurysms were located at the MCA bifurcation (46/115, 40%) and 69 at the basilar apex (60%). Thirty-seven aneurysms (32.2%) were treated with standalone coiling, 70 (60.9%) with SAC and 8 (7.0%) with BAC. Five cases required conversion from intended balloon assistance to stent assistance intra-procedurally and these were included in the stent-assisted category for evaluation. For the stent-assisted cohort, 24/70 (34.3%) patients were treated with the Neuroform stent (Stryker, Kalamazoo, Michigan, USA), 20/70 patients (28.6%) with the Enterprise vascular Reconstruction device (Codman Neurovascular, Ratham, Massachusetts, USA) and 26/70 patients (37.1%) with the Low Profile Intraluminal Support LVIS/LVIS Jr (Microvention-Terumo, Tustin, California, USA).

Table 1

Baseline characteristics (n=115)

Table 2

Aneurysm characteristics by total pool and aneurysm location

The mean maximum aneurysm diameter was 7.65 mm (SD ±2.95) and mean aneurysm neck dimension was 4.57 mm (SD ±1.59). Average dome to neck ratio was 1.48 (SD ±0.35). Average follow-up duration was 48.75 weeks (SD ±35.62, min 5, max 269 weeks) (figure 1).

Figure 1

Box plot with average clinical and radiological follow-up time in weeks for basilar aneurysms, middle cerebral artery aneurysms and the combined aneurysm pool. Interconnecting point between groups on diagram demonstrates means.

Self-reported versus core lab outcomes

For the total pool, aneurysm occlusion assessment using the modified Raymond Roy classification demonstrated a statistically significant direction towards RR1 results with self-reporting outcomes compared with independent core lab evaluation immediately following treatment (OR 1.84, 95% CI 1.15 to 2.95) and at follow-up (OR 1.75, 95% CI 1.08 to 2.83) (table 3).

Table 3

Occlusion outcomes. Initial and follow-up modified Raymond Roy scores for the pool. Comparison of self-reported and core lab review

Aneurysm groups were then separated by anatomic location and evaluated. At both initial and follow-up review, occlusion rates trended towards RR1 results with self-reporting for basilar apex aneurysms without reaching statistical significance (initial OR 1.66, 95% CI 0.9 to 3.04; follow-up OR 1.67, 95% CI 0.9 to 3.04). For MCA bifurcation aneurysms, a statistically significant direction towards RR1 results with self-reported outcomes was seen at initial evaluation (OR 2.27, 95% CI 1.06 to 4.86) and a non-statistically significant trend at follow-up (OR 1.84, 95% CI 0.85 to 3.98).

Occlusion outcomes

The core lab was unable to evaluate follow-up occlusion outcomes in two patients due to suboptimal imaging. Initial adequate aneurysm occlusion (defined as RR1 or 2), as assessed by the core lab, was demonstrated in 40.7% (RR1, 17.7%; RR2, 23%). At follow-up, adequate aneurysm occlusion was seen in 63% (RR1, 30.6%; RR2, 32.4%). Retreatment within the follow-up period was required for 10/115 aneurysms (8.7%).

In stent stenosis of <50% was seen in 5/67 patients (7.5%). The presence of in stent stenosis could not be evaluated in three patients who underwent SAC due to suboptimal imaging.

Procedural morbidity and mortality data

Baseline and follow-up mRS data were available for 105 (91.3%) and 103 (89.6%) patients respectively.

Ten of 103 patients (9.7%) suffered deterioration in their baseline mRS at clinical follow-up, with six of these patients deteriorating to mRS 3–6 (5.8%). Procedure-related mortality was 1.7% (2/115) and all cohort death or permanent disability at follow-up was seen in 6.8% of patients (7/103). The two procedure-related mortalities arose from the SAC cohort (2.8%). The first patient died on postoperative day eight following dissection of the parent basilar artery during SAC of a basilar tip aneurysm resulting in extensive subarachnoid haemorrhage and brainstem infarction. The second patient died on postoperative day 17 from respiratory arrest following holo left MCA territory infarction as a result of periprocedural parent vessel thrombosis on day one post SAC of a left MCA aneurysm despite dual anti-aggregate medication. The third patient was lost to angiographic and clinical follow-up but on discussion with the patient’s relatives was found to have died of unrelated causes.

Parent vessel dissection during the index procedure was experienced in three cases (3/115; 2.6%). Intraprocedural thromboembolic events occurred in five cases (5/115; 4.3%), with three patients experiencing a clinical deficit postoperatively but none resulting in an increase in baseline mRS at follow-up. Coil prolapse was seen in five cases (5/115; 4.3%), with three arising from the unassisted cohort and two from the stent-assisted cohort.

Five patients (5/115; 4.3%) had an intracranial haemorrhage either intraprocedurally, periprocedurally or within the follow-up time window (table 4). Four subarachnoid haemorrhages were noted, with two events occurring during the index treatment procedure (one intraprocedural aneurysm rupture, one parent vessel dissection with SAH), one periprocedural aneurysm rupture (day three postoperatively) and one delayed rupture of a treated index aneurysm 5 months postoperatively. There was one intraparenchymal haemorrhage (5.5 cm right frontoparietal intracranial haemorrhage), which occurred on day 19 post SAC of a basilar tip aneurysm. All intracranial haemorrhages occurred in the SAC population.

Table 4

Adverse events by total pool, treatment modality and aneurysm location

Discussion

Our retrospective, core lab adjudicated study of 115 patients from 10 treating centres with unruptured wide-neck aneurysms arising from the MCA bifurcation or basilar apex using FDA-approved devices demonstrates modest complete occlusion rates and durability at follow-up. This reflects the challenging nature of this subset of aneurysm and a current but potentially changing shortcoming of the FDA-approved devices available to manage them. In our series, serious adverse events occurred in eight cases (6.9%), including two procedure-related mortalities (1.7%). The majority of aneurysms treated arose from the basilar apex (60%), a location associated with significant morbidity and mortality when managed using traditional microsurgical techniques.11–13

The 2015 follow-up to the ISAT trial demonstrated that re-bleeding was more likely following endovascular coiling than after neurosurgical clipping, although there was a small increase in absolute risk.14 The same study, however, confirmed the probability of disease–free survival was significantly greater in the endovascular group than in the neurosurgical group at 10 years.

Previous studies investigating SAC have shown efficacy with excellent long-term results and satisfactory safety.15–18 However, most studies have included sidewall wide-neck aneurysms, which are known to achieve higher rates of satisfactory occlusion and none have been specifically designed using a core lab for angiographic outcomes.19 20 Despite these encouraging but self-reported results, endovascular surgery for certain aneurysm locations and morphologies has been limited by both anatomical location and technical/device-related factors. Early publications examining these lesions predated the availability of adjunctive technologies such as balloon remodelling microcatheters and dedicated neurovascular stents. These early studies demonstrated procedural safety for the endovascular treatment of wide-neck branching lesions but poor packing densities and resultant low occlusion rates of between 15% and 19%.21–23

A composite evaluation of the described modern literature to date shows a modest self-reported complete occlusion rate (RR1) of 42% (complete occlusions divided by total patients).4 6 24 25 Additionally, in a recent meta-analysis, Fiorella et al evaluated angiographic outcomes for wide-neck bifurcation aneurysms treated with either surgical clipping or endovascular techniques. The authors acknowledged many of the papers did not use core lab evaluation. They applied a core lab adjustment technique and derived adjusted RR1 and composite secured (RR1 and RR2) occlusion rates of 39.8% and 43.8% respectively for endovascular therapy.18 When level one studies were isolated, the complete occlusion rate was substantially lower (28.7%). Our core lab adjudicated study specifically evaluating MCA and basilar apex bifurcation aneurysms demonstrates complete aneurysm occlusion rates (RR1) of 30.6% at follow-up (mean 48.7±35.6 weeks) and composite secured (RR1 and RR 2) rate of 63%, which varies somewhat from Fiorella’s results.

Prior to our study, the vast majority of available data on the endovascular treatment of wide-neck bifurcation aneurysms was derived from retrospective, self-adjudicated series.4 6 24 25 Rezek et al demonstrated that retrospective, non-independently adjudicated studies will consistently overestimate treatment benefit and underestimate complication rates.26 27 Our study confirms their findings, with a statistically significant direction towards self-reporting Raymond Roy class one occlusion rates over the core lab both immediately following treatment and at follow-up (OR 1.84, 95% CI 1.15 to 2.95; and OR 1.75, 95% CI 1.08 to 2.83 respectively). This has significant implications for the evaluation of any new device undergoing regulatory approval when addressing efficacy and safety benchmarks.

Limitations

Our study has several limitations. First, while the questions and planned analysis were designed in a prospective fashion, this investigation remains a retrospective study reviewing previously performed procedures, and as such has all the bias inherent in such a design. Second, although the angiographic and clinical follow-up was available in 115 and 105 patients respectively, the reporting of events and clinical outcomes are dependent on the individual centres, which may be subject to bias and the follow-up period for the entire cohort has a broad SD. In addition, the relatively small number of balloon assisted treatment cases makes evaluation of outcomes and safety difficult to interpret with respect to this subset.

The results reflect real world practice at 10 established neuroendovascular centres in the United States and can probably be extrapolated to most centres that perform endovascular aneurysm treatment. The patient characteristics, aneurysm morphology and devices used are likely to be consistent across most centres in the United States at the time of writing.

Conclusion

This multicentre, retrospective core lab adjudicated series of 115 patients with wide-neck aneurysms arising at the MCA bifurcation or basilar apex treated by endovascular techniques using FDA-approved devices demonstrates a core lab adjudicated Raymond Roy class one occlusion rate of 30.6% at a mean follow-up of 48.8 weeks (SD ±35.6). Procedural morbidity and mortality were within published limits for this subgroup of challenging aneurysms, with 93.2% of patients being mRS 0–2 at follow-up. Self-reported results favour better angiographic outcomes. Statistically significant ORs favouring self-reporting of RR class one outcomes versus the core lab was demonstrated both immediately following treatment and at follow-up for the pool. Our study supports the ongoing need for the development and evaluation of novel endovascular devices specifically designed to treat complex intracranial aneurysms. In addition, it is imperative that any analysis of efficacy uses core lab adjudicated outcomes and that any performance criteria used are based on core lab adjudicated data.

Acknowledgments

Philanthropic funding from Daniel and Nancy Paduano supported the wages of a statistician for the study.

References

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Footnotes

  • Contributors All authors made substantial contributions to (1) the conception or design of the work, or the acquisition, analysis, or interpretation of data for the work; (2) drafting of the work or revising it critically for important intellectual content; (3) final approval of the version to be published; and are in agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Funding This work was supported by MEDTRonic Neurovascular, grant number GCO#16-0576. Further philanthropic funding was also provided by Daniel and Nancy Paduano that helped support wages for a statistician for the study.

  • Competing interests AHS, ABP, RFJ are consultants for Medtronic Neurovascular. RFJ has received research funding from Medtronic Neuorvascular. BGW is a proctor for Medtronic Neurovascular.

  • Patient consent Not required.

  • Ethics approval Multiple institutional review boards.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Data could be made available by contacting the corresponding author following IRB approval.

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