Objectives To characterize the safety and efficacy of large woven stents in the treatment of vertebrobasilar dolichoectasia (VBD).
Methods We retrospectively reviewed 19 consecutive patients with VBD treated with large woven intracranial stent (Leo stents) between January 2016 and December 2018. The clinical symptoms and angiograms of all the patients were recorded.
Results The patients were treated with 1–3 large Leo stents (5.5 mm x 75 mm, 5.5 mm x 50 mm, or 4.5 mm x 40 mm), with or without coiling. They had follow-up angiography and MRI between 3 months and 1 year. Digital subtraction angiography showed 16 patients with complete reconstruction of the target vessels, one patient with almost complete reconstruction, and two patients with partial reconstruction. All patients had symptomatic improvement shortly after treatment, but two patients developed recurrent dysphagia at 8 and 18 months, respectively.
Conclusions Deployment of woven stents with or without supportive coiling may offer symptom relief and reconstruction in patients with VBD.
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Contributors XH: substantial contributions to the conception, design of the work, analysis of date for the work, and drafting the work;. JZ: substantial contributions to acquisition of data for the work;. XL: substantial contributions to interpretation of data for the work;. XZ: revision of the article; ZL:substantial contributions to acquisition of data for the work; CD: revision of the article critically for important intellectual content and final approval of the version to be published. All authors: agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Funding This article was supported by the National Key Research Development Program (2016YFC1300804 and 2016YFC 1300800) and National Natural Science Foundation of China (81400943).
Competing interests None declared.
Ethics approval Institutional review board approval of Zhujiang Hospital was obtained for this study.
Provenance and peer review Not commissioned; externally peer reviewed.
Patient consent for publication Not required.
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