Article Text

Download PDFPDF

Original research
Mechanical thrombectomy for basilar artery occlusion: efficacy, outcomes, and futile recanalization in comparison with the anterior circulation
  1. Thomas Raphael Meinel1,
  2. Johannes Kaesmacher2,
  3. Panagiotis Chaloulos-Iakovidis1,
  4. Leonidas Panos1,
  5. Pasquale Mordasini3,
  6. Pascal J Mosimann3,
  7. Patrik Michel4,
  8. Steven Hajdu5,
  9. Marc Ribo6,
  10. Manuel Requena6,
  11. Christian Maegerlein7,
  12. Benjamin Friedrich7,
  13. Vincent Costalat8,
  14. Amel Benali8,
  15. Laurent Pierot9,
  16. Matthias Gawlitza9,
  17. Joanna Schaafsma10,
  18. Vitor M Pereira11,
  19. Jan Gralla3,
  20. Urs Fischer1
  1. 1 Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
  2. 2 Institute of Diagnostic and Interventional Neuroradiology, Institute of Diagnostic, Interventional and Pediatric Radiology and Department of Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland
  3. 3 Department for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
  4. 4 Department of Neurology, CHUV Lausanne, Lausanne, Switzerland
  5. 5 Department of Interventional and Diagnostic Neuroradiology, University Hospital of Lausanne, CHUV, Lausanne, Switzerland
  6. 6 Department of Neurology, Vall d’Hebron University Hospital, Barcelona, Spain
  7. 7 Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universität, Munich, Germany
  8. 8 Department of Neuroradiology, Centre Hospitalier Regional Universitaire de Montpellier, Montpellier, France
  9. 9 Department of Neuroradiology, Centre Hospitalier Universitaire de Reims, Reims, France
  10. 10 Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
  11. 11 Joint Department of Medical Imaging, Toronto Western Hospital, Toronto, Ontario, Canada
  1. Correspondence to Dr. Urs Fischer, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; urs.fischer{at}insel.ch

Abstract

Background Performing mechanical thrombectomy (MT) in patients with basilar artery occlusion (BAO) is currently not evidence-based.

Objective To compare patients’ outcome, relative merits of achieving recanalization, and predictors of futile recanalization (FR) between BAO and anterior circulation large vessel occlusion (ACLVO) MT.

Methods In the multicenter BEYOND-SWIFT registry (NCT03496064), univariate and multivariate (displayed as adjusted Odds Ratios, aOR and 95% confidence intervals, 95%-CI) outcome comparisons between BAO (N=165) and ACLVO (N=1574) were performed. The primary outcome was favorable outcome at 90 days (modified Rankin Scale, mRS 0-2). Secondary outcome included mortality, symptomatic intracranial hemorrhage (sICH) and FR. The relative merits of achieving successful recanalization between ACLVO and BAO were evaluated with interaction terms.

Results MT in BAO was more often technically effective and equally safe in regards to mortality and sICH when compared to ACLVO. When adjusting for baseline differences, there was no significant difference between BAO vs ACLVO regarding rates of favorable outcome (aOR 0.986, 95%-CI 0.553 – 1.758). However, BAO were associated with increased rates of FR (aOR 2.146, 95%-CI 1.267 – 3.633). Predictors for FR were age, stroke severity, maneuver count and intracranial stenting. No significant heterogeneity on the relative merits of achieving successful recanalization on several outcome parameters were observed when comparing BAO and ACLVO.

Conclusions In selected patients, similar outcomes can be achieved in BAO and ACLVO patients treated with MT. Randomized controlled trials comparing patient selection and interventional strategies seem warranted to avoid FR.

Trial registration number NCT03496064

  • angiography
  • intervention
  • stroke
  • thrombectomy
  • thrombolysis

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

View Full Text

Statistics from Altmetric.com

Footnotes

  • TRM, JK, JG and UF contributed equally.

  • Contributors TRM and JK contributed equally to this paper. TRM wrote the statistical analysis plan, cleaned and analysed the data, and drafted and revised the paper. JK designed data collection tools, drafted and revised the paper. PC-I and LPa monitored data collection of the registry. PMo, PJM, PMi, SH, MRi, MRe, CM, BF, VC, AB, LPi, MG, JS, VMP contributed to the design of the registry, and were responsible for clinical data acquisition and provided feedback on the paper. CM revised the manuscript. JG and UF supervised the project and revised the manuscript.

  • Funding This work was supported by Medtronic (Dublin, Ireland). Medtronic did not take part in the conception, design or manuscript draft of this study.

  • Competing interests UF is a consultant for Medtronic and Stryker and co-principal investigator of the SWIFT DIRECT trial (Medtronic). JG is a global principal investigator of STAR (Solitaire FR Thrombectomy for Acute Revascularisation), clinical event commitee member of the PROMISE study (European Registry on the ACE Reperfusion Catheters and the Penumbra System in the Treatment of Acute Ischemic Stroke; Penumbra), and a principal investigator and consultant for the SWIFT DIRECT study (Medtronic) and receives Swiss National Science Foundation (SNSF) grants for magnetic resonance imaging in stroke. LPi serves as a consultant for Balt, Microvention, and Penumbra. JK has received travel grants from Pfizer and Stryker. MRi serves as a consultant for Medtronic, Stryker, Anaconda, Apta Targets, and Perflow Medical and as a speaker for Neuravi. PMi has received funding for speaker honoraria from Boehringer. He has served on scientific advisory boards also for Boehringer. He has received research grants from Bristol-Myers Squibb, Boehringer, and the Swiss Heart Foundation. VMP is a consultant for Stryker (SC for DAWN trial), Penumbra (SC for PROMISE study), BALT (proctorship of products unrelated to ischemic stroke), Phenox, Rapid Medical, Neurovasc and receives research a grant from Philips. All the other authors have nothing to disclose.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Available upon reasonable request from the corresponding author after clearance by the ethical committee.

  • Correction notice Since this paper was first published online, the author V Costalat has been updated to Vincent Costalat.

  • Patient consent for publication Not required.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.