Download PDFPDF
Prevalence of large vessel occlusion in patients presenting with acute ischemic stroke: a 10-year systematic review of the literature
Compose Response

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g.
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests


  • A rapid response is a moderated but not peer reviewed online response to a published article in a BMJ journal; it will not receive a DOI and will not be indexed unless it is also republished as a Letter, Correspondence or as other content. Find out more about rapid responses.
  • We intend to post all responses which are approved by the Editor, within 14 days (BMJ Journals) or 24 hours (The BMJ), however timeframes cannot be guaranteed. Responses must comply with our requirements and should contribute substantially to the topic, but it is at our absolute discretion whether we publish a response, and we reserve the right to edit or remove responses before and after publication and also republish some or all in other BMJ publications, including third party local editions in other countries and languages
  • Our requirements are stated in our rapid response terms and conditions and must be read. These include ensuring that: i) you do not include any illustrative content including tables and graphs, ii) you do not include any information that includes specifics about any patients,iii) you do not include any original data, unless it has already been published in a peer reviewed journal and you have included a reference, iv) your response is lawful, not defamatory, original and accurate, v) you declare any competing interests, vi) you understand that your name and other personal details set out in our rapid response terms and conditions will be published with any responses we publish and vii) you understand that once a response is published, we may continue to publish your response and/or edit or remove it in the future.
  • By submitting this rapid response you are agreeing to our terms and conditions for rapid responses and understand that your personal data will be processed in accordance with those terms and our privacy notice.
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

Other responses

Jump to comment:

  • Published on:
    The AIS Denominator

    We had an opportunity to read the article by Lakomkin et al regarding systematic literature review of LVO prevalence. Since one of our studies is part of this review we feel compelled to comment on the paper. We do appreciate the authors’ efforts in conducting this analysis which is important in understanding the burden of disease – but, with respect offer some criticisms. The major limitation of the paper which the authors recognize is the heterogeneity of the included studies. Unfortunately, this limitation is so critical that it yields unreliable information at best and misleading at worst.

    The paper intends to study the prevalence of large vessel strokes. However, apart from a couple of population based studies in their review, the rest are a heterogenous mix describing an LVO rate from very selective cohorts of patients from single centers. Several are centered around validation of clinical scales for detecting LVOs. The key features of a population based study include a defined catchment population, access to a large part of that population and a reliable marker of disease. Without these a “prevalence” constitutes a report of a center’s experience of disease rate as it pertains to their patient intake. While still valuable it is not an estimation of the disease burden in the population that the center serves unless an overwhelming majority of that population comes to that center.

    The authors determine an average rate of about 30% LVO amongst acute isch...

    Show More
    Conflict of Interest:
    None declared.