Article Text

Download PDFPDF
Original research
Impaired drainage of vein of Labbé following venous sinus stenting for idiopathic intracranial hypertension
  1. Srikanth R Boddu1,2,
  2. Y Pierre Gobin1,
  3. Marc Dinkin3,
  4. Cristiano Oliveira3,
  5. Athos Patsalides1
  1. 1 Division of Interventional Neuroradiology, Department of Neurological Surgery, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, USA
  2. 2 Interventional Neuroradiology, New York Presbyterian Queens Hospital, New York, USA
  3. 3 Department of Ophthalmology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, USA
  1. Correspondence to Dr Athos Patsalides, Division of Interventional Neuroradiology, Department of Neurological Surgery New York Presbyterian Hospital/Weill Cornell Medical Center New York USA ; atp9002{at}


Purpose The impact of venous sinus stenting (VSS) on vein of Labbé (VOL) drainage is poorly understood. The purpose of the study is to examine the incidence and potential high risk factors of impaired VOL drainage among idiopathic intracranial hypertension (IIH) patients following VSS.

Materials and methods Institutional review board approved prospective evaluation of all IIH patients who underwent VSS over a 5 year period (January 2012 to December 2017) at Weill Cornell Medical Center constituted the study population. Patient demographics, procedural details (laterality of stenting, balloon angioplasty, number of stents, and stent diameters), morphology of the VOL and changes in the flow in the VOL, type of sinus stenosis, and transverse sinus symmetry were evaluated. We used χ2 analysis to evaluate impaired VOL drainage against other variables. Statistical significance was set at 0.05.

Results 70 consecutive patients (67 women, 3 men) with a mean age of 31±9.8 years underwent VSS. Stenosis was extrinsic in 63% (n=44) and intrinsic in 37% (n=26) of patients. Impaired drainage of the VOL was detected in 9/70 (13%) patients. Ipsilateral VOL was recognized as dominant in 20% (n=14), co-dominant in 51% (n=36), and non-dominant in 29% (n=20) of patients. Impaired VOL drainage was significantly associated with ipsilateral VOL dominance (P=0.001) and stent diameter of ≥9 mm (P=0.042). All patients demonstrated widely patent VOL on follow-up contrast enhanced MR venography at 3 months and 24 months.

Conclusion Impaired drainage of the ipsilateral VOL is a potential consequence of VSS with 13% incidence, and has significant association with ipsilateral superficial cortical venous drainage via dominant VOL and stent diameter of ≥9 mm.

Clinical trial registration NCT01407809.

  • intracranial pressure
  • stenosis
  • vein
  • angiography
  • intervention

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors Conception of the work: AP and MD. Acquisition of the data: AP and SRB. Analysis and interpretation of the data and drafting the work: AP and SRB. Edited the manuscript for intellectual content: all authors. Revising the manuscript critically for important intellectual content, final approval of the version to be published, and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved: all authors.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial, or not-for-profit sectors.

  • Competing interests YPG is the CEO and Medical Director and owns stocks in Serenity Medical Inc. SRB owns stocks in Serenity Medical Inc.MD has consulted for Serenity Medical Inc.

  • Patient consent Not required.

  • Ethics approval The study was approved by the institutional review board of Weill Cornell.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data available.