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Original research
Factors that determine aneurysm occlusion after embolization with the Woven EndoBridge (WEB)
  1. Christoph Kabbasch1,
  2. Lukas Goertz2,
  3. Eberhard Siebert3,
  4. Moriz Herzberg4,
  5. Jan Borggrefe1,
  6. Franziska Dorn4,
  7. Thomas Liebig4
  1. 1 Department of Neuroradiology, University Hospital of Cologne, Cologne, Germany
  2. 2 Center for Neurosurgery, University Hospital of Cologne, Cologne, Germany
  3. 3 Department of Neuroradiology, University Hospital of Berlin (Charité), Berlin, Germany
  4. 4 Department of Neuroradiology, University Hospital Munich (LMU), Munich, Germany
  1. Correspondence to Dr Lukas Goertz, Center for Neurosurgery, University Hospital of Cologne, Cologne 50937, Germany; lukas.goertz{at}


Background The Woven EndoBridge (WEB) device is a novel endovascular tool for the treatment of wide-necked intracranial aneurysms.

Objective To evaluate factors influencing aneurysm occlusion and aneurysm recurrence after WEB embolization.

Methods A total of 113 patients (mean age 58.9±11.9 years) with 114 aneurysms (mean size 8.6±4.6 mm) were successfully treated with the WEB device at three German tertiary care centers between May 2011 and February 2018. Aneurysm occlusion was evaluated using the Raymond-Roy occlusion classification. We retrospectively collected patient characteristics, anatomical details, and procedural aspects and evaluated their impact on aneurysm occlusion and recurrence.

Results Of 98 patients available for a 6-month angiographic follow-up, complete occlusion was achieved in 62.2%, neck remnants in 21.4%, and aneurysm remnants in 16.3%. Aneurysm recurrence occurred in 15.3%. Initial partial aneurysm thrombosis, recurrent aneurysms, aneurysm size, and simultaneous treatment by WEB and coil were associated with aneurysm remnants (p<0.05). Initial partial aneurysm thrombosis, increasing aneurysm size, and treatment by WEB and coil also predicted aneurysm recurrence (p<0.05).

In the subgroup analysis of 71 aneurysms treated with WEB only, initial incomplete occlusion and male sex were associated with aneurysm remnants (p<0.05), while aneurysm height correlated with aneurysm recurrence (p=0.008).

Conclusions The WEB provides a high rate of adequate occlusion even in a subset of complex wide-necked intracranial aneurysms. Anatomic results tend to be less favourable in large and partially thrombosed aneurysms and after treatment with WEB and coil.

  • aneurysm
  • coil
  • device
  • intervention

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  • CK and LG contributed equally.

  • Contributors CK, LG, ES, MH, JB, and FD acquired the data. CK, LG and TL developed the project, analyzed the data, and drafted the manuscript. All authors revised the paper critically for important intellectual content and provided final approval of the version published. All authors agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. CK and LG contributed equally as first authors.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests CK and FD serve as consultants for Acandis GmbH (Pforzheim, Germany). TL serves as proctor for MicroVention Inc./Sequent Medical (Aliso Viejo, California, USA).

  • Patient consent Not required.

  • Ethics approval According to institutional guidelines, no ethics committee approval was required for this retrospective observational study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement All data will be made available upon request in an anonymized manner.