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E-021 In vitro neurovascular model development for liquid embolic implant simulation
  1. C Settanni,
  2. T Becker,
  3. A Ducruet,
  4. W Merritt,
  5. A Huckleberry
  1. Bioengineering Devices Lab, Mechanical Engineering, Northern Arizona University, Flagstaff, AZ

Abstract

Introduction Although current microcatheter technologies have advanced in recent years, corresponding endovascular devices still lag behind. Animal models are unable to replicate consistent large and wide neck bifurcation aneurysms with sufficient neurovascular feeder vessels. Testing methods must accurately model vessel tortuosity and flow patterns. Models must detect downstream migration of neurovascular embolic devices. This paper focuses on the development and utilization of an in vitro flow model to test short- and long-term stability of a novel polymer biomaterial (PPODA-QT) for aneurysm occlusion.

Materials and methods This research project includes development of innovative in vitro aneurysm vessel model with complex side branching. This project will bring together clinical, biological, and engineering expertise. A full Circle of Willis (CW) in vitro vessel model will be fabricated into vessel analogs. This model will be constructed using a PolyJet® (UV cured) 3D printing process. UV curing creates a model with accurate anatomy and tortuosity. Typical aneurysm positions, verified by our collaborating neuro-interventional surgeon, will be 3D-printed at the basilar bifurcation, the posterior communicating (PCA) branch, and at the anterior communicating (ACA) bifurcation. Flow is regulated through the use of a Super Pump AR (ViVitro Labs). This 3D printed model will be implemented in an in vitro flow model that enables systemic data collection. A data acquisition system (DAQ) integrated with LabVIEW® software will record real time particulation images, pressure drops across the model, and flowrates through each inlet and outlet of the model.

Results and discussion The in vitro model is used to simulate and quantify short-and long-term viability of new biomaterials for brain aneurysm embolization. Delivery and balloon microcatheters access the aneurysm model from the introducer at the inlet flow-stream. Inline holography imaging quantifies the number and size of particulate in accordance with (USP) XXV<788>). The PolyJet® 3D printed model has a luminal friction 5x lower than the standard silicone vessel models. Low luminal friction improves endovascular device tracking, providing a realistic feel for surgical simulation.

Conclusions This in vitro aneurysm flow model utilizes a UV cured 3D printing technique to emulate device delivery and wear. This model provides a realistic simulation of neurovascular device delivery. Additionally, development of new biomaterials for aneurysm treatment requires models capable of replicating tortuosity and friction characteristics. Traditional additives (used to reduce wall friction) can interfere with deployment and assessment of embolics.

Disclosures C. Settanni: None. T. Becker: 1; C; Brain Aneurysm Foundation. 4; C; Aneuvas Technologies Inc. 5; C; Aneuvas Technologies Inc., Northern Arizona University. A. Ducruet: 1; C; Brain Aneurysm Foundation. 5; C; Barrow Neurological Institute, Northern Arizona University. W. Merritt:None. A. Huckleberry: 5; C; Flagstaff Medical Center.

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