Article Text

Download PDFPDF
Original research
Elevation of inflammatory S100A8/S100A9 complexes in intracranial aneurysms
  1. Antonius Mattheus de Korte1,
  2. René Aquarius1,
  3. Thomas Vogl2,
  4. Johannes Roth2,
  5. Ronald H M A Bartels1,
  6. Hieronymus D Boogaarts1,
  7. Peter L E M van Lent3,
  8. Joost De Vries1
  1. 1 Department of Neurosurgery, Radboud University Medical Center, Nijmegen, The Netherlands
  2. 2 Institute of Immunology, University of Münster, Munster, Germany
  3. 3 Department of Rheumatology, Radboud University Nijmegen, Nijmegen, The Netherlands
  1. Correspondence to Antonius Mattheus de Korte, Neurosurgery, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands; t.de.korte{at}gmail.com

Abstract

Background Inflammation-related factors might give further insight into the pathophysiology of vessel wall inflammation and intracranial aneurysm (IA) rupture. One of these factors is the protein complex S100A8/A9, which is released by neutrophils, monocytes, and activated macrophages and is known for its role in cardiovascular disease.

Objective To determine if venous S100A8/A9 levels in patients with a ruptured IA (rIA) or unruptured IA (uIA) are elevated compared with a control group. Second, to assess differences between venous and intra-aneurysmal S100A8/A9 levels of rIA and uIA patients.

Methods A prospective case study was performed between June 2016 and May 2017 in patients harboring a ruptured or unruptured saccular IA. Primary outcome measures were individual S100A8/A9 serum concentrations as measured in venous and intra-aneurysmal blood samples during endovascular treatment. Venous serum S100A8/A9 concentrations from a healthy control group served as a reference.

Results We included 16 patients with either a rIA or uIA and 47 healthy controls. Venous S100A8/A9 concentrations were higher in aneurysm patients (rIA and uIA) than those of healthy controls (P≤0.001). S100A8/A9 concentrations were higher in intra-aneurysmal samples than in venous samples of rIA patients (P=0.011). This difference was not found in uIA patients (P=0.054). Intra-aneurysmal S100A8/A9 levels were higher in rIAs than in uIAs (P=0.04).

Conclusions Venous S100A8/A9 levels are elevated in patients with both rIAs and uIAs compared with healthy controls and likely represents aneurysm wall inflammation. S100A8/A9 causes macrophage-induced inflammation and degeneration of the vessel wall which might explain higher intra-aneurysmal S100A8/A9 levels found in rIAs than in uIAs.

  • aneurysm
  • inflammatory response
  • vessel wall

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Footnotes

  • Contributors AMdK, RA, JDV, PLEMvL, HDB, RHMAB: conception, design. AMdK, JDV, RHMAA, HDB, PLEMvL, TV, JR: data acquisition, data analysis. AMdK, RA: drafting the manuscript. JDV, TV, JR, RHMAB, HD, PLEMvL, JDV: revising the manuscript. AMdK, RA, TV, JR, RHMAB, HD, PLEMvL, JV final approval of the submitted manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial, or not-for-profit sectors.

  • Competing interests Joost de Vries and Hieronymus D. Boogaarts are consultants for Stryker Neurovascular.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon reasonable request.