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Basic science
Original research
Exome sequencing reveals a novel variant in NFX1 causing intracranial aneurysm in a Chinese family

Authors

  • Xinghuan Ding Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Sen Zhao Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, China Medical Research Center of Orthopedics, Chinese Academy of Medical Sciences, Beijing, China Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Qianqian Zhang Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Zihui Yan Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, China Medical Research Center of Orthopedics, Chinese Academy of Medical Sciences, Beijing, China Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Yang Wang Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China PubMed articlesGoogle scholar articles
  • Yong Wu Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, China PubMed articlesGoogle scholar articles
  • Xiaoxin Li Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, China Department of Central Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Jian Liu Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Yuchen Niu Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, China Department of Central Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Yisen Zhang Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Mingqi Zhang Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Huizi Wang Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, China Department of Central Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Ying Zhang Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Weisheng Chen Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, China Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Xin-Zhuang Yang Department of Central Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Pengfei Liu Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Jennifer E Posey Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • James R Lupski Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA Texas Children’s Hospital, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Zhihong Wu Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, China Medical Research Center of Orthopedics, Chinese Academy of Medical Sciences, Beijing, China Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Department of Central Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Xinjian Yang Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Nan Wu Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, China Medical Research Center of Orthopedics, Chinese Academy of Medical Sciences, Beijing, China Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Kun Wang Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  1. Correspondence to Dr. Xinjian Yang, Department of Interventional Neuroradiology Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University Beijing China ; yangxinjian{at}voiceoftiantan.org, yang-xj{at}vip.tom.com, Dr. Nan Wu, Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China ; dr.wunan{at}pumch.cn and Dr Kun Wang, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; wangkun650{at}126.com
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Citation

Ding X, Zhao S, Zhang Q, et al
Exome sequencing reveals a novel variant in NFX1 causing intracranial aneurysm in a Chinese family
Journal of NeuroInterventional Surgery 2020;12:221-226.

Publication history

  • Received March 11, 2019
  • Revised July 16, 2019
  • Accepted July 18, 2019
  • First published August 10, 2019.
Online issue publication 
January 17, 2020

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© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.